By Carla Mozee, MarketWatch

Shire leads decliners

LONDON (MarketWatch) -- U.K. stocks fell Wednesday, swept lower along with other global equity market as worries about euro-zone growth and Russia's conflict with Ukraine returned to the fore.

The FTSE 100 index dropped 1.2% to 6,603.13, as oil, health-related, bank and most mining shares struggled. Stocks hit intraday lows after Italian data showed the economy was in recession in the second quarter, underscoring concerns about business conditions in the euro-zone market.

U.K. stocks had started the session lower after Wall Street, then overnight in Asia, slumped following reports Russia has dramatically increased the number of troops and vehicles at its eastern border with Ukraine, and after the Polish foreign minister warned of the potential for an invasion. On Tuesday, Russian President Vladimir Putin ordered his government to prepare retaliatory measures against U.S. and European economic sanctions imposed on Russia.

The pan-European Stoxx 600 index fell 1.3% on Wednesday.

In London, decliners on the FTSE 100 were led by a 4.3% fall in shares of pharmaceutical company Shire PLC , and respective losses of 4% and 3.6% for medical device maker Smith & Nephew PLC and drug producer AstraZeneca PLC (AZN).

Standard Chartered PLC turned 1.6% lower following a Wall Street Journal report that the bank and New York's banking regulator are in talks to settle allegations that Standard failed to flag millions of higher-risk transactions that should have undergone further review.

But Legal & General Group PLC clung to a gain of 0.1% as the insurer and fund manager posted an 11% rise in first-half operating profit and raised its interim dividend by 21% to 2.90 pence a share.

From the data front, industrial production in the U.K. rose less than forecast in June, according to figures released Wednesday by the Office for National Statistics. Production output increased by 0.3% month-on-month, against economists' estimates for a rise of 0.6%.

Meanwhile, house prices in the U.K. rose 1.4% in July on the previous month, after registering a 0.4% fall in June, according to a survey from Halifax released Wednesday. On the year, prices were up 10.2%, the largest annual gain since the start of the financial crisis in September 2007.

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