| UBS Asset Management AG | Institution | 7.774.999 | 9,76% | 665,93M € | 2026-03-31 |
| Darwin Global Management Limited | Institution | 7.728.672 | 9,70% | 661,96M € | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 6.953.681 | 8,73% | 595,58M € | 2025-07-11 |
| TCG Crossover Management, LLC | Institution | 6.481.085 | 8,13% | 555,10M € | 2026-03-31 |
| The Column Group, LLC | Institution | 6.456.596 | 8,10% | 553,01M € | 2025-09-30 |
| TCG Crossover Fund I, L.P. | Institution | 6.456.596 | 8,10% | 553,01M € | 2025-09-30 |
| JPMorgan Chase & Co. | Institution | 5.095.881 | 6,39% | 436,46M € | 2026-05-18 |
| Invus Public Equities, L.P. | Institution | 3.922.995 | 4,92% | 336,00M € | 2025-12-31 |
| Artal Group S.A. | Institution | 3.922.995 | 4,92% | 336,00M € | 2025-12-31 |
| VR Management, LLC | Institution | 3.611.570 | 4,53% | 309,33M € | 2024-12-31 |
| Sofinnova Partners SAS | Institution | 3.377.494 | 4,24% | 289,28M € | 2026-05-11 |
| Sofinnova Crossover I | Institution | 3.377.494 | 4,24% | 289,28M € | 2026-05-11 |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Institution | 3.249.885 | 4,08% | 278,35M € | 2026-06-03 |
| Deep Track Capital, LP | Institution | 3.169.862 | 3,98% | 271,50M € | 2025-07-11 |
| The Goldman Sachs Group, Inc. | Institution | 2.687.664 | 3,37% | 230,20M € | 2026-03-31 |
| Bank of America Corporation | Institution | 2.539.954 | 3,19% | 217,55M € | 2026-06-03 |
| Truffle Capital S.A.S. | Institution | 2.358.536 | 2,96% | 202,01M € | 2025-10-02 |
| Vanguard Capital Management, LLC | Institution | 2.012.655 | 2,53% | 172,38M € | 2026-05-31 |
| Lord, Abbett & Co. LLC | Institution | 1.753.276 | 2,20% | 150,17M € | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.700.934 | 2,13% | 145,68M € | 2026-05-31 |
| Morgan Stanley | Institution | 1.593.979 | 2,00% | 136,52M € | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 1.500.000 | 1,88% | 128,48M € | 2026-03-31 |
| Caligan Partners, LP | Institution | 1.461.924 | 1,83% | 125,21M € | 2026-03-31 |
| FMR LLC | Institution | 1.431.721 | 1,80% | 122,63M € | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.394.019 | 1,75% | 119,40M € | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 1.323.258 | 1,66% | 113,34M € | 2026-03-31 |
| Westfield Capital Management Company, L.P. | Institution | 1.322.938 | 1,66% | 113,31M € | 2026-03-31 |
| Helikon Investments Limited | Institution | 1.013.324 | 1,27% | 86,79M € | 2026-03-31 |
| Janus Henderson Group plc | Institution | 973.011 | 1,22% | 83,34M € | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 934.423 | 1,17% | 80,03M € | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 875.796 | 1,10% | 75,01M € | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 772.473 | 0,97% | 66,16M € | 2026-03-31 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | Institution | 765.915 | 0,96% | 65,60M € | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 760.000 | 0,95% | 65,09M € | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 691.670 | 0,87% | 59,24M € | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 677.000 | 0,85% | 57,99M € | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 675.000 | 0,85% | 57,81M € | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 655.000 | 0,82% | 56,10M € | 2025-09-30 |
| Point72 Asset Management, L.P. | Institution | 637.736 | 0,80% | 54,62M € | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 631.838 | 0,79% | 54,12M € | 2026-03-31 |
| Millennium Management LLC | Institution | 605.992 | 0,76% | 51,90M € | 2026-03-31 |
| Artia Global Partners LP | Institution | 600.747 | 0,75% | 51,45M € | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 593.897 | 0,75% | 50,87M € | 2026-05-31 |
| OrbiMed Advisors LLC | Institution | 550.150 | 0,69% | 47,12M € | 2026-03-31 |
| Citadel Advisors LLC | Institution | 544.338 | 0,68% | 46,62M € | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 542.696 | 0,68% | 46,48M € | 2026-03-31 |