PBE Invesco Biotechnology and Genome ETF

AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JULY 18, 2008.

No. 333-102228

No. 811-21265

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM N-1A

(Check appropriate box or boxes)

POWERSHARES EXCHANGE-TRADED FUND TRUST

(Exact Name of Registrant as Specified in Charter)

301 West Roosevelt Road

Wheaton, IL 60187

(Address of Principal Executive Office)

Registrant’s Telephone Number, including Area Code:  (800) 983-0903

APPROXIMATE DATE OF PROPOSED PUBLIC OFFERING:

It is proposed that this filing will become effective (check appropriate box)

o                                     immediately upon filing pursuant to paragraph (b) of Rule 485.

x                                   on August 15, 2008 pursuant to paragraph (b) of Rule 485.

o                                     60 days after filing pursuant to paragraph (a)(1) of Rule 485.

o                                     on [date] pursuant to paragraph (a) of Rule 485.

o                                     75 days after filing pursuant to paragraph (a)(2) of Rule 485.

o                                     on [date] pursuant to paragraph (a) of Rule 485.

The sole purpose of this filing is to delay the effectiveness of the Trust’s  Post-Effective Amendment No. 100 to its Registration Statement until August 15, 2008. Post-Effective Amendment No. 100 to the Trust’s Registration Statement relates to the PowerShares Autonomic Allocation Research Affiliates Portfolio, PowerShares India Tiger Portfolio and PowerShares NASDAQ Dividend Achievers Portfolio, which were created pursuant to Post-Effective Amendment No. 73 to the Trust’s Registration Statement filed on June 6, 2006.  The effectiveness of the Registration Statement was delayed pursuant to Post-Effective Amendment Nos. 82, 84, 87, 89, 94, 97, 100, 107, 110, 113, 117, 120, 123, 126, 129, 132, 135, 139, 143, 146, 149, 154, 162, 164, 168, 173, 179, 188 and 198 to the Trust’s Registration Statement filed on August 18, 2006, August 30, 2006, September 19, 2006, October 10, 2006, October 20, 2006, November 9, 2006, November 28, 2006, December 20, 2006, January 10, 2007, January 31, 2007, February 20, 2007, March 20, 2007, April 19, 2007, May 18, 2007, June 15, 2007, July 13, 2007, August 10, 2007, September 10, 2007, October 10, 2007, November 9, 2007, December 7, 2007, January 4, 2008, February 1, 2008, February 8, 2008, February 29, 2008, March 28, 2008, April 25, 2008, May 23, 2008 and June 18, 2008, respectively. Parts A, B and C of Registrant’s Post-Effective Amendment No. 100 under the Securities Act of 1933 and Amendment No. 102 under the Investment Company Act of 1940, filed on November 28, 2006, are incorporated by reference herein.

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SIGNATURES

Pursuant to the requirements of the Securities Act and the Investment Company Act, the Fund certifies that it meets all of the requirements for effectiveness of this registration statement under Rule 485(b) under the Securities Act and has duly caused this registration statement to be signed on its behalf by the undersigned, duly authorized, in the City of Wheaton and State of Illinois, on the 18th day of July, 2008.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons in the capacities indicated on the dates indicated.

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