JMBS Janus Henderson Mortgagebacked Securities ETF

[Janus Letterhead] 

May 21, 2020 

EDGAR Operations Branch 

Securities and Exchange Commission 

Division of Investment Management 

100 F Street, N.E. 

Washington, D.C. 20549-0505 

Re:Janus Detroit Street Trust (the “Registrant”) 

                     1933 Act File No. 333-207814 

                     1940 Act File No. 811-23112 

Dear Sir or Madam: 

On behalf of the Registrant, and pursuant to Rule 497(e) under the Securities Act of 1933, as amended (the “1933 Act”), transmitted herewith for filing is an interactive data file in the manner provided by Rule 405(b)(2) of Regulation S-T and General Instruction C.3.(g) of Form N-1A, containing the risk/return summary information provided in (i) the Supplement dated April 30, 2020 to the currently effective Prospectus for Janus Henderson Short Duration Income ETF, (ii) the Supplement dated April 30, 2020 to the currently effective Prospectuses for Janus Henderson Small Cap Growth Alpha ETF, Janus Henderson Small/Mid Cap Growth Alpha ETF, and The Long-Term Care ETF, and (iii) the Supplement dated April 30, 2020 to the currently effective Prospectus for Janus Henderson Mortgage-Backed Securities ETF, each filed pursuant to Rule 497(e) under the 1933 Act. 

Please call me at (303) 336-5065 with any questions or comments.  

Respectfully, 

/s/ James D. Kerr 

James D. Kerr 

Assistant Secretary 

Enclosures (via EDGAR only) 

cc: 

Byron Hittle, Esq. 

Eric Purple, Esq. 

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