| TCG Crossover Management, LLC | Institution | 7.915.567 | 6,94% | US$ 23,67M | 2026-03-31 |
| Qatar Holding LLC | Institution | 7.073.308 | 6,20% | US$ 21,15M | 2026-02-04 |
| Commodore Capital Master LP | Institution | 6.336.782 | 5,56% | US$ 18,95M | 2026-02-02 |
| Commodore Capital LP | Institution | 6.336.782 | 5,56% | US$ 18,95M | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 6.049.999 | 5,30% | US$ 18,09M | 2026-03-31 |
| Avidity Private Master Fund I LP | Institution | 5.849.999 | 5,13% | US$ 17,49M | 2026-02-20 |
| BlackRock, Inc. | Institution | 5.348.561 | 4,69% | US$ 15,99M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 4.675.000 | 4,10% | US$ 13,98M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 4.378.956 | 3,84% | US$ 13,09M | 2026-03-31 |
| Millennium Management LLC | Institution | 4.046.640 | 3,55% | US$ 12,10M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 3.957.784 | 3,47% | US$ 11,83M | 2026-02-03 |
| Citadel Advisors LLC | Institution | 3.566.504 | 3,13% | US$ 10,66M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 3.164.582 | 2,77% | US$ 9,46M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3.132.670 | 2,75% | US$ 9,37M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 2.994.460 | 2,63% | US$ 8,95M | 2026-03-31 |
| Morgan Stanley | Institution | 2.959.296 | 2,59% | US$ 8,85M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 2.627.107 | 2,30% | US$ 7,86M | 2026-03-31 |
| Ally Bridge Group | Institution | 1.981.966 | 1,74% | US$ 5,93M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.766.960 | 1,55% | US$ 5,28M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 1.625.000 | 1,42% | US$ 4,86M | 2026-03-31 |
| Nicholson Wealth Management Group, LLC | Institution | 1.618.993 | 1,42% | US$ 4,84M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.200.263 | 1,05% | US$ 3,59M | 2026-03-31 |
| Vestor Capital, LLC | Institution | 1.098.691 | 0,96% | US$ 3,29M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.003.474 | 0,88% | US$ 3,00M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 901.790 | 0,79% | US$ 2,70M | 2026-03-31 |
| Hills Bank and Trust Company | Institution | 872.200 | 0,76% | US$ 2,61M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 791.555 | 0,69% | US$ 2,37M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 752.033 | 0,66% | US$ 2,25M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 749.335 | 0,66% | US$ 2,24M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 661.318 | 0,58% | US$ 1,98M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 566.676 | 0,50% | US$ 1,69M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 528.928 | 0,46% | US$ 1,58M | 2026-03-31 |
| UBS Asset Management AG | Institution | 520.905 | 0,46% | US$ 1,56M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 450.097 | 0,39% | US$ 1,35M | 2026-03-31 |
| WealthPLAN Partners, LLC | Institution | 404.071 | 0,35% | US$ 1,21M | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 379.082 | 0,33% | US$ 1,13M | 2026-03-31 |
| FMR LLC | Institution | 313.658 | 0,28% | US$ 937,84k | 2026-03-31 |