RNS No 5193a
THERAPEUTIC ANTIBODIES INC
20 May 1999

            PROTEUS INTERNATIONAL PLC ("PROTEUS")
    THERAPEUTIC ANTIBODIES INC ("THERAPEUTIC ANTIBODIES")
    PROPOSED MERGER OF PROTEUS AND THERAPEUTIC ANTIBODIES

                                                 20 May 1999


INTRODUCTION

The Boards of Proteus and Therapeutic Antibodies are pleased
to  announce that they have agreed a share for share  merger
of   Proteus  and  Therapeutic  Antibodies  (the   "Merger")
accompanied  by  a  conditional non pre-emptive  placing  of
23,325,000 new Proteus Ordinary Shares at 40p per share (the
"Placing Price") to raise approximately #7.0 million net  of
expenses  (the "Placing") for the enlarged group,  which  at
the  Placing price has a value of #63.1 million.   Upon  the
Merger    becoming    effective,   Therapeutic    Antibodies
shareholders will receive 1.163 Proteus Ordinary Shares  for
each  Share  of Common Stock. The Merger is subject  to  the
approval  of  shareholders of both Proteus  and  Therapeutic
Antibodies.   It is expected that shareholders' meetings  of
both companies will be held in late August 1999.

Proteus is announcing today its preliminary results for  the
year  ended  31  March  1999  and  an  update  of  its  drug
development portfolio.  Included in this announcement is the
news   that  Proteus'  Angiotensin  Immunotherapeutic  anti-
hypertensive  drug  candidate  has  recently  entered  human
clinical trials.

Therapeutic  Antibodies  announced  on  18  May   1999   its
financial  results for the quarter ended 31 March  1999  and
gave  an  update  of  its drug development  portfolio.  This
announcement  contained  news that  Therapeutic  Antibodies'
Phase  IIb  study of CytoTAb in sepsis, which was terminated
early  last year, has demonstrated statistically significant
clinical results against certain  primary endpoints.

David Gration, the Chairman of Proteus, said:

"Proteus   and  Therapeutic  Antibodies  have  complementary
product portfolios, technology skills and management  teams.
The  Merger  represents  an opportunity  to  create  a  more
broadly  based,  more resilient group with a strong  product
pipeline."

Stuart Wallis, the Chairman of Therapeutic Antibodies, said:

"Proteus and Therapeutic Antibodies are two well matched
companies  whose  combination  will  create  a  stronger
platform  for enhancing shareholder value.  There  is  a
good  management fit and the combined portfolios provide
a  broader, more balanced pipeline from pre-clinical  to
launched products"

Enquiries:

Proteus                          Therapeutic Antibodies
David  Gration                   Stuart Wallis (0171 553 1483)
Barry  Riley                     Andrew Heath  (0171 606 8637)
(01625 500555)

WestLB Panmure                   British Linen Bank
Christopher Collins              Tony Brown
Ronald Openshaw                  0171 710 8800
0171 638 4010

Deloitte & Touche Corporate Finance
Robin Binks
Tim Cofman
0171 936 3000

Buchanan    Communications        The Maitland Consultancy
Tim Andersen                      William Clutterbuck
Lisa Baderoon                     Laura Frost
0171 466 5000                     0171 379 5151

THE MERGER AND ITS TERMS AND CONDITIONS

Merger ratio

Upon  completion of the Merger, each Therapeutic  Antibodies
shareholder will receive 1.163 Proteus Ordinary  Shares  for
each  Therapeutic  Antibodies Share of  Common  Stock.   The
Merger  will  involve  the issue of  up  to  60,542,545  new
Proteus  Ordinary shares (representing 81.8% of the existing
issued  share  capital) and will result in existing  Proteus
shareholders and Therapeutic Antibodies stockholders holding
55  per  cent  and 45 per cent respectively of the  enlarged
issued share capital of Proteus prior to the Placing.

The  Merger  values  each Therapeutic  Antibodies  Share  of
Common Stock at approximately 45.9p per share and the  whole
of the Therapeutic Antibodies at #23.9 million (based on the
mid-market closing price for Proteus shares of 39.5p  at  19
May   1999,  being  the  last  trading  day  prior  to   the
announcement of the Merger).

Board of Directors

It  is  proposed that Stuart Wallis, Dr Andrew Heath,  James
Christie,  Martin  Brown   and  Professor  Tim  Chard,   the
existing directors of Therapeutic Antibodies, together  with
James  Christie,  who  is currently Operations  Director  of
Therapeutic  Antibodies, will join  the  board  of  Proteus.
Stuart  Wallis will become non-executive Chairman and  David
Gration  will  become  non-executive Deputy  Chairman.   The
executive board is proposed to become:

     Chief Executive Officer   Dr. Andrew J. Heath                            
     Chief Operating Officer   Dr. Arthur Rushton
     Research Director         Dr. Allen Miller
     Manufacturing Director    James Christie  
     Finance Director          Barry Riley     


Shareholder approval

The  Merger  is  subject to the approval of shareholders  of
both  Proteus  and Therapeutic Antibodies.  It  is  expected
that  shareholders' meetings of both companies will be  held
in  late  August  1999.  Subject to such approvals  and  the
satisfaction  of certain other conditions,  it  is  expected
that  the Merger will become effective in the third  quarter
of  1999.    In order to convene the Therapeutic  Antibodies
special  shareholders'  meeting, a  Form  F-4   Registration
Statement  ("Form  F-4") must be  filed  with  and  declared
effective  by  the  US  Securities and  Exchange  Commission
("SEC").   Proteus  will  issue  listing  particulars   (the
"Listing  Particulars") describing  the enlarged group,  the
Merger  and the Placing.  The Listing Particulars will  also
comprise  a  Class 1 circular to seek Proteus  shareholders'
approval  for the acquisition.  Both shareholders'  meetings
will  be  held as soon as practicable following the date  on
which the Form F-4 is declared effective by the SEC.

To approve the Merger, the holders of at least a majority of
the  outstanding  Therapeutic Antibodies  Shares  of  Common
Stock must vote in favour of the Merger.

Principal terms and conditions of the Merger

The    Merger    Agreement   contains   certain    customary
representations   and  warranties  by   both   Proteus   and
Therapeutic Antibodies concerning their respective financial
and   business  status,  including;   (i)  organisation  and
capital  structure;  (ii) authority to complete  the  Merger
without  violating agreements or applicable law;  (iii)  the
status   of   regulatory  filings;  (iv)  the  accuracy   of
information supplied to the other party; (v) the  compliance
of   the   parties   with  applicable  law  and   regulatory
requirements;  (vi) the absence of legal proceedings;  (vii)
the  status  of tax filings; (viii) the absence  of  certain
changes since the parties' most recent financial statements;
(ix)  the status of certain employee benefit plans; (x)  the
absence  of  material  environmental liabilities;  (xi)  the
status  of  the  parties'  proprietary  rights;  (xii)   the
possession  of  necessary permits and  licences  to  conduct
business; (xiii) the absence of undisclosed liabilities; and
(xiv) title to properties.

The  Merger  is  conditional on completion of  the  Placing.
Application will be made to the London Stock Exchange for up
to  60,542,545  Ordinary Shares to be issued  in  connection
with  the Merger and 23,325,000 Ordinary Shares to be issued
in  connection  with  the Placing  to  be  admitted  to  the
Official List.

In  addition  to the matters described above, completion  of
the  Merger  is  subject  to  the  satisfaction  of  various
conditions, including the following:

-    the  continued  accuracy  of  the  representations  and
     warranties  made by Proteus and Therapeutic  Antibodies
     in the Merger Agreement;
-    the   performance  of  the  covenants  of  Proteus  and
     Therapeutic   Antibodies  set  forth  in   the   Merger
     Agreement;
-    the receipt by Proteus and Therapeutic Antibodies of  a
     tax opinion to the effect that no gain or loss will  be
     recognised  by  Proteus or Therapeutic Antibodies  upon
     completion of the Merger;
-    the  receipt  by  Proteus of a  letter  from  the  U.K.
     Treasury  that  it  consents to the completion  of  the
     Merger  for  the purposes of the Income and Corporation
     Taxes Act 1988;
-    the  absence  of any event that would have  a  material
     adverse  effect on the business or financial  condition
     of Proteus or Therapeutic Antibodies;
-    the  receipt of all consents of third parties  required
     to complete the Merger;
-    holders  of  not  more  than 2.5%  of  the  outstanding
     Therapeutic   Antibodies   Shares   of   Common   Stock
     exercising dissenters' rights under Delaware law; and
-    there  being  no  event  of  default  or  repayment  of
     borrowings  under certain Therapeutic  Antibodies  loan
     facilities.

Effect On Therapeutic Antibodies Warrants and Options

Warrants

Upon the Merger becoming effective, each outstanding warrant
to  purchase  Therapeutic Antibodies Shares of Common  Stock
will  be  converted into a warrant to purchase 1.163 Proteus
Ordinary  Shares  for each Therapeutic Antibodies  Share  of
Common  Stock covered by the warrant, for the same aggregate
purchase  price  set  forth  in the  Therapeutic  Antibodies
warrant.

1990 Stock Incentive Plan

Upon  the Merger becoming effective, each outstanding option
to  purchase  Therapeutic Antibodies Shares of Common  Stock
issued  under  Therapeutic Antibodies' 1990 Stock  Incentive
Plan  will  be  converted into an option to  purchase  1.163
Proteus  Ordinary  Shares  for each  Therapeutic  Antibodies
Share  of  Common Stock covered by the option, for the  same
aggregate  purchase  price  set  forth  in  the  Therapeutic
Antibodies option.

1997 Stock Option Plan

Upon  the Merger becoming effective, all outstanding options
to  purchase  Therapeutic Antibodies Shares of Common  Stock
issued under Therapeutic Antibodies' 1997 Stock Option  Plan
will be cancelled as provided in the plan, to the extent not
previously exercised.  Holders of options outstanding  under
the  1997  Stock  Option Plan will be entitled  to  exercise
their options, if they desire to do so, immediately prior to
the  completion of the Merger, whether or not the applicable
option vesting requirements have been satisfied.

Interests of officers and directors in the transactions

As  a  result of the Merger, the compensation package of  Mr
Gration  and the arrangements for the supply of  Mr  Wallis'
services  will  be  altered.  Mr Gration  will  become  non-
executive  Deputy  Chairman of Proteus and his  remuneration
will  be reduced accordingly. Compensation will be paid that
reflects his contractual arrangements.

Mr   Wallis  is  presently  interested  in  the  capital  of
Therapeutic  Antibodies  by an arrangement  whereby  he  may
receive  Therapeutic  Antibodies  Shares  of  Common   Stock
equivalent to 10 per cent of any increase in market value of
Therapeutic Antibodies provided certain conditions are  met.
This  arrangement  is being amended to provide for Mr Wallis
to  receive  options  to  acquire  Proteus  Ordinary  Shares
equivalent  to  4.5  per  cent of  the  increase  in  market
capitalisation of Proteus above a share price of 39.5p.   Mr
Wallis'  present  arrangement will  lapse  upon  the  Merger
becoming effective.  The proposed arrangement is subject  to
a special resolution of the Proteus shareholders at the EGM.
Further details of the arrangement will be described in  the
Listing Particulars.

THE PLACING

Proteus has entered into a conditional placing agreement  to
raise  approximately #7.0 million net of expenses by issuing
23,325,000 Ordinary Shares (the "Placing Shares") at 40p per
share,  representing  31.5 per cent of the  existing  issued
share  capital  and  14.7 per cent  of  the  enlarged  share
capital following the Merger.  The Placing shares have  been
conditionally placed by WestLB Panmure on a non  pre-emptive
basis with (non-US) institutional investors.  WestLB Panmure
has fully underwritten the Placing.

The Placing is conditional on completion of the Merger by 20
December 1999.  The proceeds from the Placing will  be  used
for  working capital following completion of the Merger  and
repayment of certain borrowings.

The  Placing will be subject to the passing of the necessary
resolutions  of shareholders at the EGM of Proteus  and  has
been  arranged  on a non pre-emptive basis  because  it  was
considered impracticable to obtain commitments from  placees
if pre-emption rights were to be offered to shareholders.

OTHER MATTERS

There  will be an analysts' presentation at 11.00 am  and  a
press  presentation at 12.30 p.m. today at  the  offices  of
WestLB Panmure at 35 New Broad Street, London EC2M 1SQ.

This announcement does not constitute an offer or invitation
to purchase any securities. The offering of Proteus Ordinary
Shares  in  exchange  for Therapeutic Antibodies  Shares  of
Common   Stock   will   be  made  only   by   means   of   a
Prospectus/Proxy Statement which it is anticipated  will  be
distributed to Therapeutic Antibodies shareholders in August
1999.

The  issue  of  this announcement has been approved  by  the
directors  of  Proteus  who accept  responsibility  for  the
information  contained within it on  Proteus  and  has  been
approved  by  the  directors of Therapeutic  Antibodies  who
accept  responsibility for the information contained  within
it on Therapeutic Antibodies.

This  announcement  has been approved for  the  purposes  of
section  57  of  the Financial Services Act 1986  by  WestLB
Panmure.

WestLB  Panmure,  which is regulated by The  Securities  and
Futures  Authority  Limited, is  acting  as  lead  financial
adviser  exclusively  for Proteus  in  connection  with  the
Merger and no-one else and will not be responsible to anyone
other than Proteus for providing the protections afforded to
customers  of  WestLB  Panmure,  or  for  giving  advice  in
relation to the Merger.

Deloitte & Touche, which is  authorised by the Institute  of
Chartered  Accountants, in England and  Wales  to  carry  on
investment  business  is acting as joint  financial  adviser
exclusively for Proteus in connection with the Merger and no-
one  else  and will not be responsible to anyone other  than
Proteus for providing the protection afforded to  clients of
Deloitte & Touche, or for giving advice in relation  to  the
Merger.

British Linen Bank, which is regulated by The Securities and
Futures  Authority  Limited, is acting as financial  adviser
exclusively  for  Therapeutic Antibodies in connection  with
the  Merger  and no-one else and will not be responsible  to
anyone  other than Therapeutic Antibodies for providing  the
protections afforded to customers of British Linen Bank,  or
for giving advice in relation to the Merger.

DEFINITIONS

The following definitions apply throughout this announcement
save where the context otherwise requires.

British Linen Bank     The British Linen Bank Limited
                       
Official List          The official list of the London
                       Stock Exchange
                       
London Stock           London Stock Exchange Limited
Exchange
                       
Merger Agreement       The agreement dated 20 May 1999
                       between Proteus and Therapeutic
                       Antibodies which sets out the terms
                       and conditions relating to the
                       merger of the companies
                       
Proteus Ordinary       The ordinary shares of 2p each in
Shares                 Proteus
                       
Proteus                Holder(s) of Proteus Ordinary
shareholder(s)         Shares
                       
SEC                    The Securities and Exchange
                       Commission in the United States
                       
Therapeutic            Share(s) of common stock of
Antibodies Common      US$0.001 each in the capital of
Stock                  Therapeutic Antibodies
                       
Therapeutic            Holder(s) of Therapeutic Antibodies
Antibodies             Common Stock
shareholder(s)
                       
U.K.                   United Kingdom
                       
U.S. or United         United States of America, each
States                 state thereof, its territories and
                       possessions and the District of
                       Columbia
                       
US$ or $               United States dollars
                       
WestLB Panmure         WestLB Panmure Limited


END


OFFPBUCPABGBUWU


Becket Invest (LSE:TAB)
Historical Stock Chart
Von Mai 2024 bis Jun 2024 Click Here for more Becket Invest Charts.
Becket Invest (LSE:TAB)
Historical Stock Chart
Von Jun 2023 bis Jun 2024 Click Here for more Becket Invest Charts.