American CareSource Holdings (Nasdaq:ANCI) (the "Company") announced today that its Board of Directors has appointed William J. Simpson as President and Chief Operating Officer. Mr. Simpson joined the Company's Board of Directors in November 2010 and was appointed Chief Operating Officer in December 2010. In addition, Kenn S. George's role as Chairman of the Company's Board of Directors has been expanded to include that of Chief Executive Officer. The appointments follow the acceptance by the Board of Directors of David S. Boone's resignation from his positions with the Company.

"Mr. Simpson has already made significant contributions during his short time with the Company," said Mr. George. "His broad knowledge of the healthcare industry and strategic vision will allow him to provide strong, dynamic leadership."

Mr. Simpson is the former President, Chief Executive Officer and Director of Intrepid USA Healthcare Inc. In addition, he has served on multiple boards, including Genezen Healthcare, where he was Chairman. In addition Mr. Simpson had held a number of executive management positions including Executive Vice President and Chief Operating Officer at LifeCare, Executive Vice President and Chief Operating Officer at Specialty Healthcare Services, Executive Vice President of Operations at Intensiva Healthcare Corporation, President and Chief Operating Officer at Ameristat Mobile Medical Services, President of Epic Healthcare Services, and Vice President of American Medical International.

About American CareSource Holdings, Inc.

American CareSource Holdings, the first national, publicly traded ancillary care network services company, offers a comprehensive national network of over 5,000 ancillary service providers at more than 36,000 sites through its subsidiary, Ancillary Care Services. Ancillary Care Services provides ancillary health care services through its network that offers cost effective alternatives to physician and hospital-based services. This market is estimated at $574 billion and has grown to over 20% of total national health expenditures. These providers offer services in 31 categories including laboratories, dialysis centers, free-standing diagnostic imaging centers, non-hospital surgery centers, as well as durable medical equipment such as orthotics and prosthetics.

The Company's ancillary network and management provides a complete outsourced solution for a wide variety of health care payors and plan sponsors including self-insured employers, indemnity insurers, preferred provider organizations, health maintenance organizations, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

The American CareSource Holdings, Inc. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=9641

ANCI-G

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995:

Any statements that are not historical facts contained in this release, including with respect to the Company's plans, objectives and expectations for future operations, projections of the Company's future operating results or financial condition, and expectations regarding the health care industry and economic conditions, are forward-looking statements. Substantial risks and uncertainties could cause actual results to differ materially from those indicated by forward-looking statements, including, but not limited to, changes in national health care policy, regulation, general economic conditions, demand for ancillary services, pricing, competition, market acceptance/preference, the Company's ability to integrate with its clients, changes in the business decisions by key clients or consolidation in the industry affecting them, the Company's inability to attract or maintain providers or clients or to manage growth, implementation and performance difficulties, and other risk factors detailed from time to time in the Company's periodic filings with the Securities and Exchange Commission. Except as otherwise required by law, the Company undertakes no obligation to update or revise these forward-looking statements.

CONTACT: Investor Contact
         Rich Cockrell
         The Cockrell Group
         Tel: 404.942.3369
         rich.cockrell@thecockrellgroup.com
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