MONEE Matrixone (MM)

With medical devices facing new regulation requirements from the FDA's 21 CFR Part 11 and Part 820 mandates, MatrixOne, Inc. (NASDAQ: MONEE), a leading provider of collaborative product lifecycle management (PLM) solutions for the value chain(TM), today announced that it will present a webcast on how managing product information electronically can significantly ease compliance efforts. Possis Medical, a manufacturer of advanced medical devices for the large and growing cardiovascular and vascular treatment market, will co-present on how the company leverages MatrixOne's integrated PLM FDA compliance solution in its business processes. Companies currently using paper-based systems to meet FDA requirements are putting themselves at risk and a competitive disadvantage. The electronic workflow provided by PLM can streamline quality assurance and compliance, while helping to improve profitability through faster time-to-market. "MatrixOne PLM provides immediate access to information, improves productivity throughout the product development process, captures data necessary for regulatory compliance, facilitates multidisciplinary collaboration and captures critical corporate knowledge," said Tim Anderson, director of engineering for Possis Medical. "The technology is a big step for us in our corporate strategy for growing our business in the years to come and introducing innovative life-saving products." -0- *T What: Free webcast entitled "Managing Regulatory Compliance Throughout Product Development" When: Wednesday, November 16, 2005 at 1:00 pm ET Who: Barry Foster, product director, MatrixOne; George Schmidt, senior PLM business consultant, MatrixOne; Rob Oveson, manager, documentation systems configuration, Possis Medical; Tim Anderson, director of engineering, Possis Medical Where: For additional information on this event or to register, please visit http://www.matrixone.com/plmlive/live.html *T About MatrixOne MatrixOne, Inc. (NASDAQ: MONEE), a leading global provider of collaborative product lifecycle management (PLM) software and services, enables companies to accelerate product innovation to achieve top line revenue growth and improve bottom line profitability. With world-class PLM solutions and a commitment to customer success, MatrixOne is focused on helping companies across the automotive, aerospace & defense, consumer, machinery, medical device, semiconductor and high-tech industries solve their most challenging new product development and introduction problems. More than 800 companies use MatrixOne's solutions to drive business value and gain a competitive advantage, including industry leaders such as BAE Systems, Bosch, Comau, General Electric, Honda, Johnson Controls, Linde AG, NCR, Nokia, Philips, Porsche, Procter & Gamble, Sony Ericsson, STMicroelectronics and Toshiba. MatrixOne (www.matrixone.com) is headquartered in Westford, Massachusetts, with locations throughout North America, Europe and Asia-Pacific. MatrixOne and the MatrixOne logo are registered trademarks and "a leading provider of collaborative product lifecycle management (PLM) solutions for the value chain" is a trademark of MatrixOne, Inc. All other trademarks and service marks are the property of their respective owners. Forward-looking statements in this release are subject to risks and uncertainties that could cause our actual results to differ materially from those anticipated. Such statements may relate, among other things, to our plans, objectives and expected financial and operating results. The risks and uncertainties that may affect forward-looking statements include, among others: poor product sales, long sales cycles, difficulty developing new products, difficulty in relationships with vendors and partners, higher risk in international operations, difficulty assimilating future acquisitions, difficulty managing rapid growth, and increased competition. For more about the risks and uncertainties of our business, see our periodic and other S.E.C. filings.