IKT Inhibikase Therapeutics Inc

Exhibit 99.1 PAH | BUSINESS PRESENTATION Clinical Development of Disease-Modifying Therapeutics for Pulmonary Arterial Hypertension Inhibikase.com : IKT

DISCLAIMER This presentation contains information that may constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act, and Section 21E of the Securities Exchange Act of 1934, as amended. Inhibikase Therapeutics, Inc. (the “Company” or “we”) intends for the forward-looking statements to be covered by the safe harbor provisions for forward-looking statements in those sections. Generally, we have identified such forward-looking statements by using the words “believe,” “expect,” “intend,” “estimate,” “anticipate,” “project,” “target,” “forecast,” “aim,” should, “will,” may”, “continue” and similar expressions. Such statements are subject to a number of assumptions, risks and uncertainties which may cause actual results, performance or achievements to be materially different from those anticipated in these forward-looking statements. You should read statements that contain these words carefully because they discuss future expectations and plans which contain projections of future clinical studies, regulatory approvals, product candidate development, results of operations or financial condition or state other forward-looking information. However, the absence of these words or similar expressions does not mean that a statement is not forward-looking. Forward-looking statements are not historical facts, but instead represent only the Company’s beliefs regarding future events, many of which, by their nature, are inherently uncertain and outside of the Company’s control. It is possible that the Company’s actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements. Management believes that these forward-looking statements are reasonable as of the time made. However, caution should be taken not to place undue reliance on any such forward-looking statements because such statements speak only as of the date when made. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. In addition, forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially from the Company's historical experience and our present expectations or projections. This presentation should be read in conjunction with the Company’s filings with the Securities and Exchange Commission, including its annual report on Form 10-K and its quarterly Form 10-Q (the “SEC Filings”). Important factors that could cause actual results to differ materially from those in the forward-looking statements are set forth in the Company’s SEC filings, including under the caption Risk Factors”. We do not intend our use or display of other entities’ names, trade names, trademarks or service marks to imply a relationship with, or endorsement or sponsorship of us by, any other entity. Inhibikase.com • : IKT 2

MULTI-THERAPEUTIC PIPELINE OF KINASE INHIBITOR THERAPEUTICS Developing innovative medicines across the therapeutic spectrum • Multi-therapeutic pipeline across cardiopulmonary disease, neurodegenerative disease and cancer. • IkT-001Pro: Prodrug of imatinib mesylate to be evaluated in Pulmonary Arterial Hypertension (PAH). Clinical 1 studies completed to quantify imatinib delivery. PAH has a $7B+ global addressable market. ➢ IND filed August 9, 2024, ‘Study May Proceed’ Letter received from FDA September 9, 2024 ➢ Phase 2 interim safety readout anticipated 4Q25/1Q26 ➢ Phase 2 top line results anticipated 4Q26 ➢ Robust patent portfolio: compositions to 2033, with extensions to 2039, PAH use to 2044 • Risvodetinib (IkT-148009): Selective c-Abl inhibitor. Phase 2 results expected November, 2024 measuring disease modification in untreated Parkinson’s disease. FDA Phase 3 meeting planned December, 2024. Phase 3 entry anticipated 2 2025. $12B+ global addressable market. • Orphan designations: IkT-001Pro in pulmonary arterial hypertension under review. • Highly-experienced management team, consultants, Board of Directors and Scientific Advisory Board. 1 2 From Biomedtracker (Citeline Commercial), 2024 (https://www.biomedtracker.com/indicationreport.cfm?indid=245#PipelineChart) ; Vision Research, 2022 Inhibikase.com • : IKT 3

IkT-001Pro for Treatment of Pulmonary Arterial Hypertension IIn nh hiib biik ka as se e..c co om m • • :: IIK KT T 4 4

1 PULMONARY ARTERIAL HYPERTENSION: A COMPLEX DISEASE WITH MORTALITY ON PAR WITH CANCER PAH mortality on par with many Complex disease etiology leading to narrowing 2 1 Cancer Indications of lung microvasculature Dysfunctional Pulmonary Epithelium • Vasodialators and vasoconstrictors working against one another COMPERA: Comparative, Intermediate Risk Dysfunctional Vascular Smooth Muscle • Sustained vasoconstriction Prospective 20% 3 yr mortality Registry of Newly Initiated Therapies for Pulmonary Hypertension; FPHR: French Persistent inflammation and immune Pulmonary High Risk dysregulation Hypertension 40% 3 yr mortality • Excessive infiltration of inflammatory Registry; mediators REVEAL: The • Perivascular inflammatory cell Registry to infiltration Evaluate Early and Long‐Term PAH Disease Management. 1 Humbert et al. Lancet Respir Med (2023); 11:804-819 2 Chang et al., JAHA (2022); 11:e024969 Inhibikase.com • : IKT 5

1 NEW TREATMENT OPTIONS FOR PULMONARY ARTERIAL HYPERTENSION REMAIN A HIGH UNMET NEED Only 1 approved Disease Modifying drug: Sotatercept (Merck). No oral disease-modifying therapies approved 1 2023 Sales ($B) for existing therapies that only treat symptoms $1.9 Projected sales by 2026 $2.6 for first approved disease modifying 1 therapy $1.3 1 Currently a $5B market in the US alone; $.7.6B globally 1 From Biomedtracker (Citeline Commercial), 2024 (https://www.biomedtracker.com/indicationreport.cfm?indid=245#PipelineChart) ; Inhibikase.com • : IKT 6

CURRENT STANDARD OF CARE AND THE POTENTIAL ROLE OF IMATINIB 1 Imatinib inhibits the Platelet-derived growth factor receptor (PDGFR), blocking cell signaling that drives 2 proliferation. Shown to be disease-modifying Sotatercept Anti-prostacyclin ERAs Sotatercept blocks a different proliferative pathway. imatinib 3 Shown to be disease-modifying and approved. PDE5i PDGFR 1 1 Adapted from Tuttle, et al., Curr Opin Nephrol Hypertens 2024, 33:494–502 2 3 Hoeper et al. Circulation. 2013;127:1128-1138; Hoeper et al. New Engl. J. Med.(2023); 16:1478ff Inhibikase.com • : IKT 7

HISTORY OF IMATINIB THERAPY IN PAH 2010: Small proof-of-concept trial demonstrates 2013: P3 IMPRES trial -> Imatinib hits stat 2005: Off-label use of imatinib elicits disease that Imatinib improves hemodynamics and sig on primary endpoint of 6MWD as well 1 control in advanced PAH patient 2 3 6MWD in PAH patients. as key secondary endpoint PVR. ≈40m 1 Ghofrani et al, N Engl J Med. 2005;353:1412–1413 2 Ghofrani et al., Am J Respir Crit Care Med. 2010;182:117 3 Hoeper et al. Circulation. 2013;127:1128-1138 Inhibikase.com • : IKT 8

IMATINIB AND SOTATERCEPT HAVE COMPARABLE EFFICACY Imatinib data from Ph3 IMPRES has comparable efficacy to Sotatercept from Ph3 STELLAR 1-5 data PULMO NA RY VASCULA R RESISTA NCE 6-MINUTE WA LK DISTAN CE 0 50 Placebo Adjusted Values -50 45 40 -100 35 -150 30 -200 25 -250 20 -300 15 -350 10 -400 5 -450 0 I M A T I N I B P H 2 I M A T I N I B P H 3 I M A T I N I B P H 3 S O T A T E R C E P T S O T A T E R C E P T I MA T I N I B P H 2 I M A T I N I B P H 3 I M A T I N I B P H 3 S O T A T E R C E P T S O T A T E R C E P T Placebo Adjusted Values 2 0 0 M G * 4 0 0 M G * P H 2 P O O L E D P H 3 2 0 0 M G * 4 0 0 M G * P H 2 P O O L E D P H 3 * Patient spent majority of trial at this dose * Patient spent majority of trial at this dose 4 Sotatercept only improved disease in 30% of STELLAR participants. There remains a significant unmet need. 1 2 Humbert et al, J Engl J Med. 2021; 384:1204-1215; Ghofrani et al., Am J Respir Crit Care Med. 2010;182:117 3 4 Hoeper et al. Circulation. 2013;127:1128-1138; Hoeper et al. New Engl. J. Med. (2023); 16:1478ff 3 No head-to-head trials have been conducted leading to the results shown. As a result no cross-trial comparisons can be made. Inhibikase.com • : IKT 9 Meters Dynes Sec CM-5

Why imatinib failed to be approved IIn nh hiib biik ka as se e..c co om m • • :: IIK KT T 10 10

SERIOUS ADVERSE EVENTS IN THE IMPRES STUDY Imatinib was not approved because of high discontinuation rate in IMPRES Ph3 1-2 AEs mimicked disease symptoms as such mimicry could suggest clinical worsening Adverse Events included: • Subdural Hematoma • Edema and Fatigue may mimic symptoms of disease • GI: Gastrointestinal AEs including nausea and diarrhea 1 Hoeper et al. Circulation. 2013;127:1128-1138. 2 Frost et al., J. Heart Lung Transplantation 2015; 34:1366-1375. Inhibikase.com • : IKT 11

SOLVING THE PROBLEMS WITH IMATINIB: SUPPRESSION OF SUBDURAL HEMATOMA ALL patients with subdural hematoma treated with old-style anti-coagulants 1-2 Subdural hematoma didn’t occur in the absence of anti-coagulants Imatinib significantly increases exposure of the anti- coagulants used in these patients via Cyp inhibition. Subdural hematoma incidence: 1 2/103 patients in the core study (1.9%) 2 6/144 patients in the extension study (4.2%) 1. Anti-coagulant use no longer standard-of-care in PAH. 2. Imatinib has significant DDI with older anti-coagulants used in IMPRES ➢ DDI with newer anti-coagulants like Eliquis thought to be modest. 3. Subdural hematoma is a known AE associated with Imatinib therapy in cancer, occurring in <1% of patients with CML on 3 chronic imatinib Anti-coagulant use will be prohibited in the upcoming trial with IkT-001Pro 1 2 3 Hoeper et al. Circulation. 2013;127:1128-1138; Frost et al., J. Heart Lung Transplantation 2015; 34:1366-1375; Druker et al, N Engl J Med 2001 Apr 5;344(14):1031-7 Inhibikase.com • : IKT 12

SOLVING THE PROBLEMS WITH IMATINIB: PROPERLY ANALYZING ADEVERSE EVENTS LIKE EDEMA 1-2 From IMPRES manuscript GI and edema adverse event rate on Imatinib is similar in IMPRES and contemporary CML trials. However, discontinuation rate was AEs largely similar to those much higher in IMPRES. seen in other imatinib studies. AE frequency and discontinuation rate across 3 Imatinib studies 70% Imatinib induced edema 60% mistaken for worsening of 50% PAH. 40% 30% 20% High discontinuation rate 10% likely driven by lack of physician experience with 0% drug. Nausea rate Edema rate Diarrhea rate Vomiting rate AE-related discon rate IMPRES core and extension Blended CML trials Hoeper et al. Circulation 2013 Clinical worsening will be adjudicated by Data Monitoring Committee in planned trial 1 2 3 Hoeper et al. Circulation. 2013;127:1128-1138; Frost et al., J. Heart Lung Transplantation 2015; 34:1366-1375; Druker et al, N Engl J Med 2001 Apr 5;344(14):1031-7 Inhibikase.com • : IKT 13

SOLVING THE PROBLEMS WITH IMATINIB: FREQUENCY OF GI SIDE EFFECTS DEPENDS ON DOSE Adverse Placebo Imatinib Adverse Imatinib Imatinib 1 2 2 Event (n=98) (n=103) Event 200-300mg 350-500mg % Occurrence % Occurrence Nausea 23 (24%) 57 (55%) Nausea 30% 50% Diarrhea 19 (19%) 36 (35%) Diarrhea 4% 33% Vomiting 13% 11% Vomiting 10 (10%) 31 (30%) 1 2 Frequency of GI disturbance in IMPRES Lower frequency of GI disturbance at lower doses IkT-001Pro was developed to suppress GI adverse events and shown to achieve this in non-human primate studies 1 2 Hoeper et al. Circulation. 2013;127:1128-1138; Druker et al, N Engl J Med 2001 Apr 5;344(14):1031-7 Inhibikase.com • : IKT 14

Imatinib delivery by prodrug IIn nh hiib biik ka as se e..c co om m • • :: IIK KT T 15 15

SOLVING THE PROBLEMS WITH IMATINIB: MASKING THE CHEMICAL SURFACE DRIVING GI AEs IkT-001Pro, a prodrug of imatinib, designed to mask imatinib at the gut wall 4-carbon atom linker imatinib linker gut wall + pH 2-6 pH 7 (blood) (stomach, ileum, duodenum) Lifetime in blood < 10 min Inhibikase.com • : IKT 16

IkT- 001Pro IS A SMALL MOLECULE IMATINIB PRODRUG IkT-001Pro: Anticipated lower GI toxicity alternative to imatinib Measurement of IkT-001Pro orally delivered once daily in Non-Human Primates RESULTS SUGGEST POTENTIAL No Adverse Event Level TO: Doses studied Cmax Tmax AUC 0-T (mg/kg/day) (mg/kg/day) (mean, ng/mL) (mean, h) (mean, ng-h/mL) ✓ Achieve dose flexibility, NOAEL including use of higher dosing 176/206 4/3 1540/1960 Imatinib due to lower AEs 15 1 (91 days) (M/F) (M/F) (M/F) ✓ Suppress GI and other adherence-related adverse 400/318 5.3/3.7 IkT-001Pro 5220/3890 25, 75, 150 75 (28 days) (M/F) (M/F) (M/F) events ▲ NO A DVERSE EVENTS ▲ Up to 3.4x Up to 3.4x higher dose of imatinib increased exposure delivered as 001Pro 1 Imatinib data taken from FDA summary data for approval #21-335 available at Drugs@FDA Inhibikase.com • : IKT 17

C (ng/mL) max CLINICAL EXPERIENCE WITH IkT- 001Pro Bioequivalence and Linear PK over the effective range Dose Linearity of 001Pro • Bioequivalence of IkT-001Pro 60000 3500 established to cover a dosing y = 62.101x + 4087.3 range between 230 and 600 R² = 0.9126 3000 50000 mg imatinib delivered • No clinically meaningful side 2500 40000 effects observed from single doses over this range. 2000 y = 2.7327x + 320.59 30000 • No meaningful GI disturbance R² = 0.9169 1500 observed from single doses over the range. 20000 1000 • PK analysis performed with two-period crossover studies 10000 500 over a total of 66 participants 0 0 200 300 400 500 600 700 800 AUC Cmax Linear (AUC) Linear (Cmax) Inhibikase.com • : IKT 18 AUC (ng-h/mL) 0-inf

CHOOSING THE RIGHT DOSE OF IkT- 001Pro IKT-001Pro at bioequivalent dose to 400 mg imatinib observed to Trough concentrations observed in human cancer have comparable exposures in humans patients or in PAH Oral Dose C Trough observed trough IMPRESS 1 1 2 (mg) (ng/mL) (ng/mL) 140 279 ± 38 300 886 ±752 400 1216 ± 750 125 to 1200 Projected trough need to saturate target: 200 to 250 ng/mL Projected Imatinib Equivalent Imatinib IKT-001Pro Dose 1 C Dose trough 300 mg QD ≈600 ng/mL 240 mg QD 500 mg QD ≈1100 ng/mL 380 mg QD 1 2 ACS Omega 2023, 8, 13741−13753; Renard et al., Br J Clin Pharmacol 2015; 80:75–85 Inhibikase.com • : IKT 19

IkT- 001Pro POTENTIAL AS A BRANDED DRUG IN PAH Regulatory and IP Status: IkT-001Pro is a New Molecular Entity for PAH Pre-IND Meeting with FDA April 5, 2024 IP protection out to 2039-2044+ • Agency agreed that lower dosing, improved safety Composition of Matter profile in NHP studies may mitigate safety concerns of • Protection to 2033/4 IMPRES; Agency was keen to see this proceed • 2038/9 with Patent Term Extension • Agency agreed 505(b)(2) is an appropriate approval Method of Use in PAH path for IkT-001Pro • Protection anticipated to 2044 (without • Agency agreed NME exclusivity applies to IkT-001Pro including PTE) • Orphan Drug designation already under review • No blocking IP from NVS • Unique dosing + novel compositions of matter and use will extend patent exclusivity to 2044. • Patent Pending • Agency agreed special designations/accelerated Other layers of Protection approval could be sought (e.g. Breakthrough, Fast-Track, • Dosing, DDI, etc. etc.). • To be Filed Other layers of protection available • Drug-drug interactions Inhibikase.com • : IKT 20

ADVANTAGES OF 001Pro in PAH Summary of why imatinib delivered by IkT-001Pro could be impactful • IkT-001Pro is a Phase 3 ready asset for PAH following IND clearance • Imatinib is proven to be effective in PAH • High unmet need to improve the lives of patients, sotatercept isn’t enough • IP protection as an NME with exclusivity over the patent life, which we believe will run into 2044 • Imatinib has well-understood, long-term safety/tolerability and patient management • If IkT-001Pro is efficacious, safe and tolerable, IkT-001Pro should be eligible for Breakthrough Designation • Program has potential for simpler/faster path to approval on 505(b)(2) as an NME Inhibikase.com • : IKT 21

OUTLINE OF IKT-001PRO DEVELOPMENT PROGRAM Ph2b Trial (Registrational?) Ph3 Trial N=150 Primary EPs: Primary EPs: Placebo Placebo N~160 1:1:1 - PVR - 6MWD IKT001-Pro 300 mg 1:1 • No anti-coagulants or - Safety >1 anti-platelet IKT001-Pro Selected Dose randomization IKT001-Pro 500 mg therapy • Stratify sotatercept No anti-coagulants or * 80% powered to show a 30m * 80% powered to show a 25% • 50% PVR > 800 dyne- 5 >1 anti-platelet s/cm at entry reduction in PVR improvement in 6MWD Wk 24 Wk 24 therapy allowed. HYPOTHETICAL EXECUTION TIMELINE 2H 2024 2025 2026 2027 2028 IND Ph2b Ph3 Anticipated Topline in 2026 Anticipated Topline in 2029 Estimated costs/burn for illustration + ~$105M USD ~$100M USD ≈$205M only; actual costs may vary Inhibikase.com • : IKT 22

LEADING CLINICAL SCIENTISTS IN PAH DEDICATED TO COMPANY’S PAH PROGRAM Dr. Marc Humbert, MD Dr. Marius Hoeper, MD President of the European Respiratory Society, Marc Marius M. Hoeper, MD, is deputy director of the Humbert is Professor of Respiratory Medicine, Vice Dean Department of Respiratory Medicine at Hannover for Research and Director of the Inserm Unit 999 at Medical School, Hannover Germany, where he is also in Université Paris-Saclay, France. He is the Director of the charge of the pulmonary hypertension (PH) program and Department of Respiratory and Intensive Care Medicine, senior attending physician at the intensive care unit. As Pulmonary Hypertension Reference Centre Hôpital Bicêtre, clinician scientist, he has published more than 400 papers Assistance Publique Hôpitaux de Paris, France. Marc in these areas. Professor Hoeper was a task force Humbert was the Chief Editor of the European Respiratory member/chair at the 3rd, 4th, 5th and 6th World Journal from 2013 to 2017 and he is currently Section Symposia on PH. He was also an author and Section Editor for Pulmonary Vascular Medicine. He has received Editor of the 2009 and 2022 European PH Guidelines and distinctions. Since 2017, Marc Humbert is the vice- the senior author of the 2015 European PH Guidelines. In coordinator of the European Reference Network for rare 2014, Professor Hoeper received the distinguished and low prevalence respiratory diseases (ERN-LUNG). Since Lifetime Achievement in Pulmonary Arterial Hypertension 2018, Clarivate Analytics has listed Marc Humbert as one Award from the European Respiratory Society, and in of the world's highly cited researchers in the field of 2016, he received the Oskar award for Medicine. In 2018 Clinical Medicine. and 2019, Clarivate Analytics listed Professor Hoeper as Highly Cited Researcher. THE MOST PUBLISHED CLINICAL INVESTIGATOR PRINCIPAL INVESTIGATOR OF IMATINIB AND WORLDWIDE IN PAH SOTATERCEPT TRIALS; HIGHLY PUBLISHED CLINICAL PARTICIPATED IN IMATINIB AND SOTATERCEPT TRIALS INVESTIGATOR IN PAH Will BE PRINCIPAL INVESTIGATOR OF TRIAL Inhibikase.com • : IKT 23

Lessons from IMPRES -> ‘Imatinib is an efficacious drug for patients with PAH. With contemporary trial design and Inhibikase’s prodrug approach, I believe IkT001-Pro can be a differentiated therapy for patients.’ Marius Hoeper, MD Inhibikase.com • : IKT 24

ABOUT US / EXECUTIVES Management Team with Deep Experience in Drug Development and Commercialization Milton Werner, PhD Garth Lees-Rolfe C. Warren Olanow, MD, President & CEO Chief Financial Officer Medical Consultant and Chief Executive Officer of Clintrex Research Corporation. Previously, Dr. Werner served as Director of Previously served as our Vice Research at Celtaxsys. From September 1996 until President of Finance from Dr. Olanow is the former Henry P. and Georgette Goldschmidt Professor and Chairman of June 2007, Dr. Werner was a Head of the November 2022 to March 2024. the Department of Neurology at the Mount Sinai School of Medicine Prior to joining Mount Laboratory of Molecular Biophysics at The Prior to Inhibikase served as the Sinai, he served on the faculties of McGill University, Duke University, and the University of Rockefeller University in New York City. Throughout Vice-President, Finance for F- South Florida. He is the former President of the Movement Disorder Society, past President of the International Society of Motor Disturbances, and former Treasurer of the American his scientific career, Dr. Werner has been an Star, Inc., a publicly traded global Neurological Association. He has served on the executive committee of the Michael J. Fox innovator integrating chemistry, physics, and biology clinical-stage biotech company. Foundation Scientific Advisory Board, and he is the former Chairman of the Scientific into a comprehensive approach to solving problems Prior to his corporate work, spent 16 Advisory Board of the Bachmann-Strauss Parkinson Foundation and of the Dystonia in medicine. Dr. Werner is the author or co-author of years in public practice mostly with Foundation. Dr. Olanow is the former Co-Editor-in-Chief of the journal Movement Disorders. more than 70 research articles, reviews, and book Ernst & Young, lastly as a Senior Dr. Olanow received his medical degree from the University of Toronto, performed his chapters and has given lectures on his research Manager. He is a licensed Certified neurology training at the New York Neurological Institute at Columbia Presbyterian Medical work throughout the world. Public Accountant in the state of Center at Columbia University, and undertook postgraduate studies in neuroanatomy at Massachusetts and a licensed Columbia University and authored more than 600 articles in the field of neurodegeneration. Chartered Accountant of Australia and New Zealand. Inhibikase.com • : IKT 25

PAH | APPENDIX Clinical Development of Disease-Modifying Therapeutics for Pulmonary Arterial Hypertension Inhibikase.com : IKT Inhibikase.com • : IKT 26

SUMMARY ADVERSE EVENTS Adverse Events observed during bioequivalence clinical studies # Occurrences # Occurrences # occurrences # occurrences Category Severity Category Severity 1 600 mg IkT-001Pro 400 mg imatinib mesylate 800 mg IkT-001pro 600 mg imatinib mesylate 1 1, 2 1 (n=8) (N=64) (N=55) (n=8) 1 Ocular 1 Mild Dry eyes 2 1 Gastrointestinal Mild 5 3 Gastrointestinal Mild Sporadic loose stool Nausea Gassy, bloated, abdominal Loose stool, reduced 1 Neurological Mild discomfort or loose stool appetite, nausea Loss of appetite (7 days) 1 1 Respiratory Mild 1 800 mg IkT-001Pro studied, 900 mg computed equivalent dose Labored breathing Labored breathing Dermatological 1 Mild Itchy ankles Musculoskeletal 5 6 Mild Myalgias, joint pain Myalgias, joint pain Neurological 2 2 Mild Headache Headache 1 Mild Anxiety 1 Mild Sleepiness 1 One subject accounts for 14 of the 25 adverse events observed; 6 of the total events on IkT-001Pro and 8 2 of the total events on 400 mg imatinib mesylate; The 300 mg 001Pro cohort did not have a 400 mg imatinib mesylate comparator (N=3) Inhibikase.com • : IKT 27

INCLUSION CRITERIA FOR THE 702 TRIAl INCLUSION 1. Men and women between the ages of 18 and 70 years of age (inclusive) at the time of signing the informed consent. 2. Capable of giving signed ICF which includes compliance with the requirements and restrictions listed in the ICF and in this protocol. 3. Documented diagnostic right heart catheterization (RHC) at any time prior to screening confirming the diagnosis of WHO PAH Group 1 in any of the following subtypes: a. Idiopathic PAH b. Heritable PAH c. Drug/toxin-induced PAH d. PAH associated with CTD e. PAH associated with simple, congenital systemic-to-pulmonary shunts at least 1 year following repair 4. Symptomatic PH classified as WHO FC II or III 5. Baseline RHC performed during the Screening Period documenting a minimum PVR of . . -5 ≥ 400 dyn sec cm (≥5 WU) and a pulmonary capillary wedge pressure (PCWP) or left ventricular end-diastolic pressure of ≤ 15 mmHg 6. On stable doses of background PAH therapy (i.e., patient-specific dose goal for each therapy already achieved) for at least 90 days prior to screening; for infusion prostacyclins, dose adjustment within 10% of optimal dose is allowed per medical practice. a. For those taking sotatercept their dosing regimen should be stable for at least 6 months prior to screening 7. 6MWD ≥ 150 and ≤ 500 m repeated twice at screening (measured at least 4 hours apart, but no longer than 1 week), and both values are within 15% of each other (calculated from the highest value). Inhibikase.com • : IKT 28

EXCLUSION CRITERIA FOR THE 702 TRIAL EXCLUSION 1. Diagnosis of PAH WHO Groups 2, 3, 4, or 5 14. Currently receiving moderate or strong Cytochrome P450 (CYP) 3A4/5 inducers or CYP3A4/5 2. Diagnosis of the following PAH Group 1 subtypes: human immunodeficiency virus (HIV)- inhibitors (except for topical administration) associated PAH and PAH associated with portal hypertension. Exclusions in PAH Group 1 should 15. History of pneumonectomy also include schistosomiasis-associated PAH and pulmonary veno-occlusive disease 3. Evidence of three or more (≥ 3) of the following left ventricular disease/dysfunction risk factors: 16. Currently receiving or anticipated need to receive anticoagulants 1. Body mass index (BMI) ≥ 30 kg/m2 at the Screening Visit 17. Currently receiving or anticipated need to receive more than one anti-platelet medication. 2. History of essential hypertension The use of prostacyclins is not considered exclusionary. Note that sotatercept is not 3. Diabetes mellitus – any type considered anti-platelet therapy 4. Historical evidence of significant coronary artery disease (CAD) established by any one of the following: 18. Initiation of an exercise program for cardiopulmonary rehabilitation within 90 days prior to 1. History of myocardial infarction the screening visit or planned initiation during the study (participants who are stable in the 2. History of percutaneous coronary intervention (PCI) maintenance phase of a program and who will continue for the duration of the study are 3. Angiographic evidence of CAD (> 50% stenosis in at least one vessel) eligible) 4. Positive stress test with imaging 19. History of atrial septostomy within 180 days prior to the screening visit 5. Previous coronary artery surgery 6. History of chronic stable angina or unstable angina 20. Current participation in another investigational clinical trial and/or receipt of any 4. Uncontrolled systemic hypertension as evidenced by sitting systolic BP > 160 mmHg or sitting investigational medication within 90 days prior to screening diastolic BP > 100 mmHg during screening visit after a period of rest 21. Previous randomization into this or another IkT-001Pro study 5. Baseline systolic BP < 90 mmHg at screening 22. Any social or behavioral reason that would preclude completion of the study, in the 6. Clinically significant orthostatic hypotension judgement of the investigator 7. History of restrictive, constrictive, or congestive cardiomyopathy 23. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 3 8. Electrocardiogram (ECG) with Fridericia’s corrected QT interval (QTcF) ≥ 450 msec in males or ≥ times the upper limit of normal (ULN) 470 msec in females during the Screening Period or ≥500 msec in the presence of a right 24. Bilirubin levels greater than 3 times the upper limit of normal (ULN) bundle branch block. 2 25. Estimated glomerular filtration rate (eGFR) < 30 mL/min/m (as defined by the Modification 9. Personal or family history of long QT syndrome (LQTS) or sudden cardiac death of Diet in Renal Disease [MDRD] equation) 10. Pulmonary function tests (PFT) completed no more than 24 weeks before the screening period 26. Currently lactating, pregnant or planning on becoming pregnant during the study (or completed at the Screening Visit). Following criteria must are considered exclusionary 1. TLC and/or FVC < 70% 2. FEV1 < 65% 3. FEV1:FVC ratio ≤ 0.60 4. DLCO < 45% except for CTD-PAH 11. Left ventricular ejection fraction (LVEF) < 50% at screening. 12. Cerebrovascular accident within 3 months prior to the screening visit 13. Acutely decompensated heart failure within 30 days prior to the screening visit, as per investigator assessment Inhibikase.com • : IKT 29

® SIGNNIFICANT UNMET NEED REMAINS DESPITE RECENT APPROVAL OF SOTATERCEPT (WINREVAIR ) Sotatercept (SC Q3W) was approved in 2024 as the first disease modifying therapy 1 Sotatercept demonstrated 6-minute walk and PVR benefit However, only a minority of PAH patients respond to Sotatercept in a clinically 1 meaningful way Sotatercept developer Acceleron was acquired for $11.5B by Merck in 2021 2 following positive Phase 2 data 1 2 Hoeper et al. New Engl. J. Med. (2023); 16:1478ff.; https://www.merck.com/news/merck-to-acquire-acceleron-pharma-inc/ Inhibikase.com • : IKT 30

IMATINIB DEMONSTRATED A DOSE-RESPONSIVE BENEFIT IN PAH • IMPRES Ph3 Trial titrated patients from 200 mg QD for first 2 weeks to 400 mg QD if well tolerated. If not well tolerated, 1 patients remained on 200 mg QD. • 24/67 patients on imatinib were not able to stay on the 400 mg dose for ≥50% of the treatment period and kept dose at 200 mg for majority of treatment. These patients showed significant PVR and 6MWD improvements. These benefits were seen 1 independent of background therapy 1 Hoeper et al. Circulation. 2013;127:1128-1138 Inhibikase.com • : IKT 31

COMPETITION FOR TKIs Competitive landscape for TKIs 1 • Inhaled Seralutinib : Phase 2 trial outcome demonstrates inhaled seralutinib < 1/3 as effective as sotatercept/imatinib in haemodynamics, modest 6MWD improvement across all classes. 1 Poster, American Thoracic Society Annual Meeting, May 19-24, 2023 Inhibikase.com • : IKT 32

COMPETITION FOR TKIs Competitive landscape for TKIs 1 • Inhaled imatinib : Phase 2b studies of AV-101 demonstrate no efficacy whatsoever. Why? 2 Trough imatinib AV-101 on repeat dosing Trough imatinib in IMPRES 1 250 to 1250 ng/mL 534 ng/mL with 90 mg BID AV-101 Phase 2 trial only used 70 mg BID 1 2 Renard et al., Br J Clin Pharmacol 2015; 80:75–85; Gillies et al. ERJ Open Res 2023; 9: 00433-2022 Inhibikase.com • : IKT 33

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