Two affiliates of Steven A. Cohen's embattled SAC Capital Advisors agreed to pay more than $614 million to settle separate civil insider-trading probes, the Securities and Exchange Commission said Friday.

One of those affiliates, CR Intrinsic Investors, agreed to pay more than $600 million to settle a civil lawsuit filed by the SEC in November, representing the largest settlement ever for allegations of insider trading, the regulator said.

The settlements come as clients of SAC Capital have moved to pull $1.7 billion from the hedge-fund firm as federal insider-trading probes have weighed on the firm.

At least six former employees have been ensnared in the government's investigation. However, SAC has said the firm and its founder, Mr. Cohen, have acted appropriately and will cooperate in the government's probe.

In the Intrinsic case, the SEC alleged that the affiliate traded on nonpublic information regarding the clinical trial of an Alzheimer's drug. Mathew Martoma, a former Intrinsic portfolio manager, is separately facing criminal charges related to the alleged trades and has denied wrongdoing.

"The historic monetary sanctions against CR Intrinsic and its affiliates are sharp warning that the SEC will hold hedge fund advisory firms and their funds accountable when employees break the law to benefit the firm," said George S. Canellos, acting director of the SEC's Division of Enforcement.

In a statement, SAC said that the firm was happy to resolve the matters. "This settlement is a substantial step toward resolving all outstanding regulatory matters and allows the firm to move forward with confidence," the firm said. "We are committed to continuing to maintain a first-rate compliance effort woven into the fabric of the firm."

"SAC's business decision to settle with the SEC in no way changes the fact that Mathew Martoma is an innocent man," said Charles A. Stillman, a lawyer for Mr. Martoma. "We will never give up our fight for his vindication."

On Friday, Sigma Capital Management, another SAC affiliate, also agreed to pay nearly $14 million to settle a separate lawsuit by the SEC, alleging that the firm engaged in insider trading of shares ahead of the quarterly earnings announcements of Dell Inc. (DELL) and Nvidia Corp. (NVDA).

The information allegedly was obtained by Jon Horvath, a former Sigma Capital analyst who pleaded guilty to criminal charges and agreed to cooperate in the government's probe.

"Sigma Capital's violations of the securities laws were blatant and recurring," said Sanjay Wadhwa, senior associate director of the SEC's New York regional office. "The firm obtained key quarterly earnings information before it was public and exploited an unfair edge over the rest of the market to reap millions of dollars in unlawful gains."

-- Michael Rothfeld and Juliet Chung contributed to this story.

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