CXSP Chemgenex Pharmaceuticals Ltd (MM)

ChemGenex Pharmaceuticals Limited (ASX:CXS and NASDAQ:CXSP) announced today the publication of a report in the prestigious Nature publication Leukemia confirming the positive clinical activity of the company�s lead compound, Ceflatonin� against Gleevec�-resistant, chronic myeloid leukemia (CML) associated with the T315I Bcr-Abl mutation. The T315I mutation is known to confer resistance to both Gleevec (imatinib mesylate) and second-generation tyrosine kinase inhibitors (dasatinib and nilotinib). Recent publications indicate that the incidence of T315I-associated resistance is increasing and confirm that this mutation is likely to become the prevalent mutation in those who fail tyrosine kinase inhibitor therapy. The publication by Dr. Laurence Legros of the H�pital Archet, Nice, France and colleagues describes the treatment with Ceflatonin (homoharringtonine, HHT) of a Gleevec-resistant, chronic-phase CML patient with the T315I Bcr-Abl mutation. The authors report that the patient experienced a 50 percent reduction of T315I Bcr-Abl levels within 2.5 months of treatment initiation, and the complete disappearance of the mutation within 5.5 months of treatment. Complete hematological response (CHR) was achieved after three cycles of therapy. Based on the clinical results, the authors believe that the rapid and complete disappearance of the T315I mutation might suggest a particular sensitivity of this mutation to HHT. The authors conclude that HHT �may provide an alternative therapeutic treatment option for CML patients with the T315I mutation, for whom therapies have been previously lacking.� The authors also noted some hematologic toxicities (neutropenia, thrombocytopenia and anemia), but confirmed that the toxicity of HHT was �easy to manage�. �We are delighted with this publication that reinforces our belief in the potential of Ceflatonin to treat patients with the T315I Bcr-Abl mutation,� said Greg Collier, Ph.D., Chief Executive Officer and Managing Director of ChemGenex. ChemGenex is currently treating patients in two clinical studies that are designed to support the filing of New Drug Applications (NDAs) for the treatment with Ceflatonin of sub-sets of CML patients. The first study, is for Gleevec-resistant patients with the T315I point mutation and the complementary second study is for CML patients who are resistant to, or intolerant to treatment with two or more tyrosine kinase inhibitors. �We believe that Ceflatonin offers significant potential as a therapeutic alternative for these unserved and growing CML patient populations,� Dr Collier added. Publication details BCR-ABLT315I transcript disappearance in an Imatinib-resistant CML patient treated with Homoharringtonine: A new therapeutic challenge? Leukemia advanced online publication May 31, 2007. Laurence Legros1, Sandrine Hayette2, Franck E. Nicolini3, Sophie Raynaud4, Kaddour Chabane2, Jean-Pierre Magaud2, Jill-Patrice Cassuto1, Mauricette Michallet3 1 Hematology Department, H�pital Archet 1, 06202 Nice, France; 2 Laboratory for cytogenetics and molecular biology and EA3737, Centre Hospitalier Lyon Sud, 69495 Pierre-B�nite, France; 3 Hematology Department, H�pital Edouard Herriot, 5 place d�Arsonval 69437 Lyon, France; 4 Hematology Laboratory, H�pital Archet 2, 06202 Nice, France. Ceflatonin� is a registered trademark of ChemGenex Pharmaceuticals Limited. Gleevec�/Glivec� is a registered trademark of Novartis AG. About ChemGenex Pharmaceuticals Limited (www.chemgenex.com) ChemGenex Pharmaceuticals is a pharmaceutical development company dedicated to improving the lives of patients by developing therapeutics in the areas of oncology, diabetes and obesity. ChemGenex harnesses the power of genomics for target discovery and validation, and in clinical trials to develop more individualized therapeutic outcomes. ChemGenex�s lead compound, Ceflatonin�, is currently in phase 2/3 clinical trials for chronic myeloid leukemia (CML) and Quinamed� is in phase 2 clinical development for prostate, breast and ovarian cancers. The company has a significant portfolio of anti-cancer, diabetes and obesity programs, several of which have been partnered with international pharmaceutical companies. ChemGenex currently trades on the Australian Stock Exchange under the symbol "CXS" and on NASDAQ under the symbol "CXSP". Safe Harbor Statement Certain statements made herein that use the words �estimate,� �project,� �intend,� �expect,� �believe,� and similar expressions are intended to identify forward-looking statements within the meaning of the US Private Securities Litigation Reform Act of 1995. These forward-looking statements involve known and unknown risks and uncertainties which could cause the actual results, performance or achievements of the company to be materially different from those which may be expressed or implied by such statements, including, among others, risks or uncertainties associated with the development of the company�s technology, the ability to successfully market products in the clinical pipeline, the ability to advance promising therapeutics through clinical trials, the ability to establish our fully integrated technologies, the ability to enter into additional collaborations and strategic alliances and expand current collaborations and obtain milestone payments, the suitability of internally discovered genes for drug development , the ability of the company to meet its financial requirements, the ability of the company to protect its proprietary technology, potential limitations on the company�s technology, the market for the company�s products, government regulation in Australia and the United States, changes in tax and other laws, changes in competition and the loss of key personnel. 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