TIDMAVIA 
 
Avia Health Informatics plc 
 
                        (formerly Avia Investments plc) 
 
                          Admission to trading on AIM 
 
                 Placing to raise GBP1.18million at60p per share 
 
               Acquisition of The Plain Software Company Limited 
 
Avia Health Informatics plc (AIM: AVIA) (`Avia' or `the Company'), the 
developer and provider of clinical decision support systems worldwide, 
announces that it has completed the acquisition of The Plain Software Company 
Limited (`Plain'), and that dealings on AIM have commenced. 
 
HIGHLIGHTS 
 
  * Cancellation from trading on PLUS, reverse takeover and admission to AIM 
 
  * Placing to raise GBP1.18 million before expenses at a placing price of 60p 
    per share 
 
  * Acquisition of The Plain Software Company Limited completed. Plain develops 
    and delivers clinical decision support systems for primary and emergency 
    healthcare markets in the UK and internationally 
 
  * Plain Odyssey software suite supports triage, assessment and advice for 
    first line patient contacts, including out-of-hours services, GP practices, 
    emergency medical services, walk-in centres, prisons and insurance 
    companies 
 
  * Over 60 per cent of Primary Care Trusts commissioned out-of hours services 
    in England use Odyssey, covering around 30 million people 
 
  * Plain has in excess of 60 contracts with customers for installation, 
    licences and support - more than 20 per cent of these customers have been 
    with the company for over five years 
 
  * Extensive, proprietary, clinical database developed over the past 15 years 
    by teams of doctors, nurses and academics. Software is wholly owned by the 
    Company and its design draws on Bayes' theorem of conditional and marginal 
    probability 
 
  * New .NET version of Odyssey developed; service-orientated architecture and 
    web-deployed version is under development. 
 
Chairman, Barry Giddings, commented: 
 
"Plain has significant growth potential and by investing in product 
development, we are confident of being able to accelerate its growth. It is 
also an operational platform on which Avia can build, through organic growth 
and via acquisition. These will be complementary and will enhance market 
penetration, providing access to new markets as well as improving product 
usability and function. 
 
"Health informatics is a fast-moving, growing market with a large number of 
small, underfunded businesses, many with excellent products and intellectual 
property but without the commercial support to realise their potential. 
 
"Our aim is to build a global healthcare informatics business in an expanding 
market." 
 
                                                               16 November 2009 
 
Enquiries: 
 
Avia Health Informatics plc 
 
Barry Giddings, Chairman                                          07770 747 818 
 
Nigel Leavy, Finance Director                                     07966 013 421 
 
Merchant John East Securities Limited (Nominated Adviser and Broker) 
 
Simon Clements/Bidhi Bhoma                                        020 7628 2200 
 
Lothbury Financial (Financial PR) 
 
Gary Middleton/Michael Padley                                     020 7011 9411 
 
Introduction 
 
Avia Investments plc announced on 27 February 2009 that it had entered into a 
conditional agreement to acquire the entire issued share capital of Plain, a 
company which operates in the healthcare technology sector. The consideration 
for the Acquisition was approximately GBP1.6 million satisfied by the issue of 
2,501,662 Consideration Shares at the Placing Price and the payment by the 
Company of GBP105,000 in cash. 
 
Background 
 
Avia was admitted to trading on PLUS on 25 March 2008 with the objective of 
making equity investments in the healthcare technology sector. On 27 February 
2009, the Company announced that it had made a secured loan of GBP100,000 to 
Plain in order to provide the company with additional working capital and allow 
it to expand its current activities, prior to the Acquisition. Avia also 
announced on 27 February 2009 that it had signed a conditional agreement to 
acquire Plain and trading of the Company's shares was temporarily suspended 
from trading on PLUS pending the publication of this document. 
 
The Directors have significant experience in the medical, healthcare, software 
and technology sectors and intend to grow the Enlarged Group through both the 
expansion of existing trade and by further acquisitions. 
 
Background information on Plain 
 
Plain develops and delivers clinical decision support systems for primary and 
emergency healthcare markets in the UK and internationally. Its Odyssey 
software suite supports triage, assessment and advice for first line patient 
contacts, including out-of-hours services, GP practices, emergency medical 
services, walk-in- centres, prisons and insurance companies. 
 
Plain was founded in February 1995 by Prof. Jeremy Dale, Robert Crouch and 
Michael Bennett, to develop and market clinical decision support software for 
primary care workers. 
 
Prof. Jeremy Dale is Plain's Clinical Director and a non-executive director of 
Avia. 
 
Plain's initial product was a telephone triage clinical decision support 
system, (known as "TAS"), which recorded its first sale in November 1995. TAS 
was selected as one of three systems for the then new NHS Direct. In 1998, an 
independently-led randomised control trial research study into the safety and 
effectiveness of nurse telephone consultation using TAS in out-of-hours primary 
care, the SWOOP study, showed cost savings and efficiency gains that could be 
achieved as a result of an improved clinical assessment using TAS. 
 
The study found that nurses using the product were at least as effective as GPs 
in out-of-hours telephone consultations. This in turn reduced demands on 
doctors' time while allowing for savings in staffing costs. 
 
TAS was initially selected by nine of the 17 NHS Direct pilot sites and was 
also supplied to GP out-of-hours and walk-in-centres in the UK. However, in 
2000, the NHS Direct tender was awarded to the AXA group using an American 
decision support system which had not been one of three original systems 
trialled. As a result, Plain lost its NHS Direct contracts, forcing a major 
retrenchment of the business. Subsequently, the management team refocused their 
efforts on markets not addressed by NHS Direct, targeting out-of-hours and face 
to face care. TAS was re-designed and re-launched as `TAS Odyssey' in 2002. 
 
In 2003, MedicInfo B.V. ("MedicInfo") in Holland acquired 10 per cent. of 
Plain's issued capital, becoming a strategic partner and distributor of Odyssey 
in Holland. Due to further share issues in 2003 and 2005 the shareholding of 
MedicInfo was diluted to 9.6 per cent. of the company. Plain currently receives 
fees for the provision of six Odyssey contracts in Holland. 
 
The tender process for out-of-hours decision support was relaxed in 2003 by 
allowing competitive tenders to NHS Direct. In 2005, Plain supplied 32 per cent 
of PCT commissioned out-of hours services in England using Odyssey. In 2008, 
this had grown to over 60 per cent Currently, around 30 million people in the 
UK are covered by out-of-hours services using Odyssey products. 
 
In 2007, Barry Giddings was brought in as a consultant to help develop the 
Plain business. He was subsequently appointed as Chairman and Managing Director 
of the company. The Board and management team were restructured with additional 
focus placed on the sales and marketing function, product design and technical 
development expertise to complement the existing clinical and academic 
expertise. 
 
In 2009, Plain, with the assistance of a secured loan from Avia, commenced the 
development of a new .NET version of Odyssey. 
 
Clinical database 
 
Plain's products, further details of which are provided below, are based on an 
extensive, proprietary, clinical database developed over the past 15 years by 
teams of doctors, nurses and academics. The Odyssey clinical database currently 
comprises age/sex specific interlinked symptom-based question sets, each of 
which includes questions and potential answers together with self-care advice, 
immediate care advice, differential diagnosis, examination and care plan 
guidance and prompts and education text. Every question has multiple potential 
answers, each of which carries a weighting, and it is the cumulative analysis 
of the weighted responses that determines the advice that the patient receives. 
The database has over 50,000 questions and answers with 13,000 potential 
examination findings covering sets of symptoms specifically relating to adults, 
children and the elderly. A team of clinicians led by Dr. Mark Vorster is 
responsible for reviewing and updating the entire clinical content on an 
on-going basis. 
 
All clinical content is encrypted to prevent copyright infringement. 
 
The decision support software 
 
The proprietary software is wholly owned by the Company. Its design draws on 
Bayes' theorem of conditional and marginal probability to evaluate and analyse 
clinical information input by the user against decision support criteria which 
are stored in the clinical database. This differs from algorithmic approaches, 
as adopted by Plain's primary competitors, since typically such systems lead 
the user through rigidly structured "yes/no" based questions and without the 
ability to alter previous answers without restarting the data entry. The 
Directors believe that Plain's system has the advantage of imitating natural 
consultation and decision making processes, so allowing the clinician to 
respond flexibly to a patient's description of symptoms. 
 
The National Programme for IT requires industry standard communication 
protocols, the most recent being HL7 Version 3 which is essentially an 
XML-based mark-up standard intended to specify the encoding, structure and 
semantics of clinical documents for exchange. XML makes it possible to define 
the content of a document separately from its formatting, making it easy to 
reuse that content in other applications or for other presentation 
environments. This is especially important for systems that share structured 
data, particularly across the Internet, and for adaptable applications that are 
either translated into different world languages or which are frequently 
updated. 
 
All Odyssey systems currently use XML for communication and Odyssey is capable 
of being embedded into third party systems which provide the requisite link to 
the National Spine. 
 
Applications 
 
All products are marketed under its `Odyssey' brand. Odyssey comprises a suite 
of applications, which between them allow both non-clinically trained staff and 
clinicians to assess and process patients efficiently and safely. The products 
are designed for easy inter-operability and cross-platform integration and are 
embedded into the patient administration system used by the majority of the 
UK's out-of-hours GP services. The products can also be integrated with other 
national and international patient administration systems and ambulance 
management systems. 
 
The products are available either via annual subscription, quarterly 
subscription (if 10 or more licences are purchased) or on a consumption basis, 
in the case of Odyssey Pay As You Go. Customer support, education and 
consultancy advice is an integral part of the product offering. Regular and ad 
hoc updates of clinical content are included in subscription fees. 
 
The products have been translated into German, French, Italian and Dutch and 
are already in use in these languages. 
 
The current product suite comprises four stand-alone decision support front-end 
applications and an integrated set of three of the applications: 
 
Odyssey TeleAssess 
 
Plain's first application, originally known as `TAS', was launched in 1995 and 
subsequently rebranded. Odyssey TeleAssess supports clinician-led telephone 
triage and provides up to date clinical advice for patient assessment. In the 
UK, it is used primarily by both out-of-hours services and by GP surgeries 
in-hours to efficiently manage patient care. 
 
Internationally, Odyssey TeleAssess is currently used in the Netherlands and 
the Republic of Ireland for out-of-hours services, by health insurance 
companies in Switzerland and the Netherlands and by an attendance management 
company in the United States. 
 
Odyssey FaceToFace 
 
Odyssey FaceToFace was launched in 2005, targeted at Walk-in Centres and 
similar nurse-led clinics. It supports nurses who carry out direct patient 
consultation providing assessment and examination decision support, 
documentation and care management plans. In addition to providing access to the 
clinical database and assessment system, Odyssey FaceToFace also has the 
capability to capture and annotate digital photographs and x-rays which are 
stored in the patient's records. 
 
It is currently in use in the UK by NHS walk-in-centres and primary care 
centres staffed by varying grades of nurses and, more recently, it is also 
being used by the prison service. 
 
Odyssey Reception 
 
Odyssey Reception was developed in 2006 to support non-clinician decision 
making with respect to the prioritisation of patient queues and the 
identification of potential emergencies. 
 
The product is aimed primarily at call handlers and receptionists throughout 
primary care services. It has been designed to allow easy operation without 
prior medical knowledge. Odyssey Reception presents short sets of age and 
gender specific questions, based on the patient's symptoms, and subsequently 
allocates the patient to the most appropriate grade of available medical staff 
to deal with the severity or complexity of the matter. 
 
Odyssey Gold 
 
Odyssey Gold is a combination product which comprises Odyssey TeleAssess, 
Odyssey FaceToFace and Odyssey Reception combined into one suite. This allows 
for simple integration and information sharing across the product range, from 
initial call through to a face to face consultation. 
 
Odyssey Pay As You Go 
 
Applications can also be made available to lower volume users who are charged 
on a per patient encounter basis. 
 
Odyssey SelfAssess 
 
Odyssey SelfAssess was developed for pilot site use from February 2009 and is 
an on-line self assessment decision support system, created by Plain for 
individuals wanting to assess their symptoms and acute healthcare needs, and 
gain access to healthcare advice and/or the need and urgency of contacting a 
healthcare provider. It supports patients to characterise their problem through 
answering questions connected to the symptoms they are presenting, in just the 
same way as a doctor or nurse might explore their history. 
 
Odyssey eCover 
 
Odyssey eCover was launched to enable telephone triage of patients during a 
public health crisis. It is the first of Plain's web-delivered products and is 
currently being marketed to help primary care trusts manage the pandemic swine 
flu outbreak. 
 
Odyssey FirstAssess 
 
Odyssey FirstAssess is to replace the versions of Odyssey FaceToFace and 
Odyssey Reception now being used to improve healthcare within prisons, 
supporting high levels of achievement against many of the Offender Health 
Prison Health Performance and Quality Indicators and offering leading clinical 
decision support. 
 
Odyssey FirstAssess is currently in development to offer enhanced functionality 
designed for use in the HM Prison environment. 
 
Odyssey ParaMedic 
 
Odyssey ParaMedic is currently in development for pilot use in the `SAFER' 
trials with Swansea University and three ambulance services. Embedded into a 
mobile system on board ambulances it is designed to empower paramedics to make 
decisions regarding the safety of taking patients home rather than to hospital, 
thereby saving the health economy significant resources. Initial trials are 
being planned and focus on elderly patients suffering falls. 
 
Odyssey TAS 
 
Odyssey TAS is a Dutch-market specific version of Odyssey TeleAssess. 
 
Additional services 
 
Plain offers a range of additional fee earning services that support the 
Odyssey products including implementation, technical support, training and 
consultancy. These services are self-contained and can be purchased on an ad 
hoc basis by existing customers or by non-customers. 
 
Migration to .NET 
 
Plain has developed a new .NET version of Odyssey, which is currently being 
evaluated by a customer. In order to dramatically open up new market 
opportunities, the current product requires an updated delivery mechanism which 
reduces the significant intervention requirements associated with installation, 
training and support on client-server networks. By redesigning the software 
delivery of the clinical content, Avia will be able to service existing Odyssey 
clients more efficiently via the SaaS model, especially with regard to 
technical and clinical upgrades, while also enabling the opening of significant 
new markets for global expansion. 
 
Specifically these new markets include; GP Surgeries, Care Homes, Ambulance 
Services, Prisons and crucially the distribution of Odyssey products by sales 
channel partners. 
 
In order to migrate the products onto a new technology platform, Plain is 
developing a service orientated architecture ("SOA"). This will allow the 
development of products that can be; deployed locally on a device (PC/tablet PC 
/mobile phone in the future); embedded in 3rd party applications and hosted in 
a SaaS solution held in secure data centres in regional and national locations. 
 
Development of software that is web deployed (i.e. click on a link and it will 
install on a local machine) and web enabled (access it directly through a web 
browser either hosted on a local network or central server) has been commenced. 
The following stages have been taking place over the past six months and will 
continue into the first quarter of 2010. These represent the key stages of the 
development lifecycle of Odyssey.NET SOA. 
 
  * Initial Exploration: including an `intellectual property harvest' of the 
    current product range. 
 
  * Prioritisation: of the results of the IP harvest to define the scope of 
    planned development. 
 
  * Design: performed mainly by the .NET Solution Architect and working closely 
    with both internal and external customers to identify requirements. 
 
  * Training: a significant amount of effort is being applied to training of 
    existing staff, through structured training events, weekly development 
    training sessions and peer programming. 
 
  * Development: the development process involves a series of 2-6 week 
    iterations, known as sprints, intended to focus on a prioritised set of 
    objectives, or storyboards. 
 
  * Building: framework services (demographics, security, clinical etc). 
 
Delivering: at the same time delivering saleable products for the business - to 
this aim, the Odyssey eCover application is the first .NET product to market. 
 
Testing: this is crucial to delivering high-quality product to the marketplace 
- the philosophy of the Odyssey.NET SOA is to test early and test often. 
 
It is envisaged that although the final delivery of the .NET SOA will not be 
until Q2 2010, Plain has released certain products and applications already. A 
refined version of Odyssey eCover is expected in Q4 2009 and will provide 
additional opportunities in the global markets. This initial release will 
contribute to the release of the full Odyssey.NET TeleAssess product, to be 
undertaken in 2010. To assist the roll out of these products Plain will rely on 
close cooperation with its partners and discussions are progressing well with 
all major suppliers to the group's existing markets. 
 
Plain is cooperating with key third party suppliers for the Clinical Content 
service for TeleAssess to allow close integration of these tools within their 
own product development which is expected to lead to additional revenues. 
 
The Directors believe that the .NET architecture offers significantly enhanced 
ease of use and flexibility and will enable Avia to target both a wider patient 
base and a wider geographical coverage. 
 
Within all of the Odyssey applications is a comprehensive and secure audit 
trail, documenting details such as times, dates, symptoms and advice given. 
 
Financial summary of Plain 
 
The table below contains information extracted from the audited financial 
information for Plain for the three financial periods ended 31 March 2009 and 
research and development expenditure for those three years. 
 
                                          Audited        Audited        Audited 
 
                                     12 months to   12 months to   13 months to 
 
                                      28 February    29 February       31 March 
 
                                             2007           2008           2009 
 
                                            GBP'000          GBP'000          GBP'000 
 
Revenue                                     1,615          1,547          1,878 
 
Profit/(Loss) before tax                       71            112          (217) 
 
R&D Expenditure charged against               173            245            136 
profits 
 
For the period up to 31 December 2008, Plain's research and development 
expenditure has been fully written off in the year in which it was incurred. 
From 1 January 2009, development expenditure is capitalised when it meets the 
criteria set out for recognition in International Accounting Standard 18 and 
amortised over its useful economic life. In the financial statements for the 13 
months ended 31 March 2009, GBP31,141 was capitalised. 
 
Plain has incurred trading losses in the 13 months ended 31 March 2009 as a 
result of the recruitment of 18 employees in order to further expand and 
develop its operations. 
 
Market background 
 
Clinical decision support technology has grown in response to the needs of 
governments and healthcare providers to improve the safety, efficiency and 
effectiveness of healthcare services in the face of increased expectations, 
demands and costs. A key area for cost savings comes from the more effective 
use of skilled nursing staff, allied health professionals and healthcare 
assistants who, to help relieve the pressure on doctors' time, can assume 
greater responsibility for certain roles and patient assessments which have 
historically been undertaken by doctors. This not only increases doctors' 
access to patients with more complex or urgent needs, therefore improving 
waiting times and care levels, but can also reduce overheads. Clinical decision 
support software can support clinical processes from patient self assessment to 
telephone and face to face nurse or receptionist assessment in areas as diverse 
as pharmacies, prisons, ambulances and insurance. It can also provide rigorous 
documentation and audit trails in the event of insurance and litigation. 
 
The UK healthcare market has changed in recent years. The consolidation of 
Strategic Health Authorities and the reduction in number of Primary Care Trusts 
from 309 to 152 in 2006 and English Ambulance Trusts from 31 to 13 attempted to 
standardise services and to centralise budgets and purchasing decisions. On the 
other hand, there has been a move towards greater competition in the delivery 
of services; for example, increasing use of the private sector for the 
provision of services such as out-of hours, GP-led health centres 
(`polyclinics'), emergency medicine and an increasingly important role for high 
street pharmacists. The increase in alternative primary care services such as 
walk-in- centres and polyclinics coupled with acknowledged gaps in clinical 
assessment skills, opens the market for effective clinical decision support 
technology. 
 
The out-of hours market accounts for over 60 per cent. of Plain's current 
turnover. Plain has a dominant position in this market with almost two thirds 
of PCTs using the Odyssey support services or related products in which Odyssey 
is incorporated. 
 
Revenue model 
 
Plain sells a range of services to the primary care sector, primarily derived 
from interrogation of its clinical database. 
 
Customers pay an annual subscription fee based on the chosen software 
application. Subscription fees also include charges for maintenance and updates 
of the clinical data. Training and enhanced training courses are offered for an 
additional fee. 
 
It is the intention of the Enlarged Group to supplement the current range of 
front-end applications for the database with additional products covering areas 
such as emergency departments, long term condition management, the Ministry of 
Defence and ambulance services, as well as health insurers, via self diagnosis 
systems, care homes, pharmacies and health advice lines. It is envisaged that 
the revenue model will remain the same with subscription charges being levied 
on a per user basis. 
 
Customers 
 
Plain has in excess of 60 contracts with customers for installation, licences 
and support. More than 20 per cent of these customers have been with the 
company for more than five years. These clients are primarily UK based, with 
six customers currently coordinated via the strategic alliance with MedicInfo 
B.V. Plain also has customers in the USA, Switzerland and Ireland. 
 
At present, approximately 60 per cent. of revenue is derived from the sale of 
services to out-of-hours services providers with a further 23 per cent. 
directly to walk-in centres. 
 
Competitors 
 
Competitors range from large multinational operators to smaller single sector 
businesses and compete directly with UK based algorithmic systems providers. It 
also competes indirectly with doctor-led services where there is a less 
accepted need for clinical decision support packages. Clinical Solutions (CAS) 
is currently the largest competitor of the business with software used by NHS 
Direct, other health advice lines and walk-in centres. Additional competitors 
in the UK include Nightingale Guidelines and NHS Pathways. International 
competitors include McKesson, a US market leader in the insurance sector, 
Fonemed and PSIAM, a product from Priority Solutions Inc. which offers a fully 
automated clinical content product integrated with ambulance services. 
 
Product Development 
 
Plain intends to further invest in software and market development to access 
new markets, which include emergency departments, long term conditions, 
sickness and absence management, care homes, and increase penetration of 
existing markets such as ambulance, insurance, prison sectors, and the armed 
forces. Future development will focus on: 
 
  * developing a service orientated architecture that will provide discrete 
    services such as security, demographics or clinical assessment to third 
    party systems. This will facilitate integration of clinical content and 
    improve user experience; 
 
  * providing a flexible workflow model that allows healthcare services to 
    adapt the system to their practice; 
 
  * enhancing security services to improve protection of patient 
    confidentiality; and 
 
  * creating flexible user interfaces to enable products to operate on a wide 
    range of devices including touch screens, mobile devices and tablet PCs. 
 
Future strategy for the Enlarged Group 
 
The Directors intend to develop and grow the Enlarged Group both organically 
and through a "buy and build" strategy. The Company will target complementary 
businesses with strong management teams which will operate alongside Plain, 
enhancing market penetration and providing access to new markets as well as 
improving product usability and function. 
 
Current trading and prospects of the Enlarged Group 
 
Current trading is in line with Plain's historical performance for the period 
ended 31 March 2009 and with management's expectations. These expectations are 
based on Plain's long term strategy to recruit new personnel and train and 
enhance the skills of existing personnel as required to develop and deliver 
`.Net' products and services from the fourth quarter 2009. The strategy also 
includes the further deployment of web enabled products and services for 
delivery in 2010 and its classic product range for delivery to a wider customer 
base in existing markets in late 2009. 
 
Development in .NET has progressed throughout the second and third quarter 2009 
with product delivery for both research and commercial release. The research 
and development release of the Odyssey SelfAssess.NET product has been 
successfully web deployed and has been well received by both GPs and the 
patients that have used the system. 
 
The Directors are pleased with the progress that has been made over the past 
few months and anticipate the proceeds of Placing having a significant effect 
on the outlook for 2010. 
 
Share capital statistics 
 
Placing Price 60p 
 
Number of Placing Shares to be issued 1,975,100 
 
Number of Consideration Shares to be issued 2,501,662 
 
Number of Ordinary Shares to be issued to providers of services in lieu of fees 
160,980 
 
Number of Ordinary Shares in issue following Admission 4,950,249 
 
Placing Shares as a percentage of the Enlarged Issued Share Capital 39.90 per 
cent 
 
Consideration Shares as a percentage of the Enlarged Issued Share Capital 50.54 
per cent 
 
Market capitalisation of the Company at the Placing Price on Admission GBP2.97 
million 
 
Gross proceeds of the Placing GBP1.185 million 
 
Cash consideration for the Acquisition GBP105,000 
 
Net proceeds of the Placing GBP1.02 million 
 
Terms defined in the admission document dated 20 October 2009 have the same 
meaning in this announcement. 
 
 
 
END 
 

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