CHAPMAN AND CUTLER LLP 111 West Monroe Street
Chicago, Illinois 60603

March 1, 2013

Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549

Re: First Trust Series Fund (the "Registrant")
File No. 333-168727

Ladies and Gentlemen:

On behalf of the Registrant, in accordance with the provisions of Rule 497(j) of Regulation C under the Securities Act of 1933, as amended, (the "Securities Act"), this letter serves to certify that the most recent amendment to the Registration Statement on Form N-1A (the "Registration Statement") of the Registrant does not differ from that which would have been filed pursuant to Rule 497(c) of the Securities Act. The Registration Statement relates to First Trust Preferred Securities and Income Fund and First Trust/Confluence Small Cap Value Fund, each a series of the Registrant. Post-Effective Amendment No. 9, which was the most recent amendment to the Registration Statement, was filed electronically with the Securities and Exchange Commission on February 28, 2013.

If you have any questions or comments, please telephone the undersigned at
(312) 845-3484.

Very truly yours,

CHAPMAN AND CUTLER LLP

By: /s/ Morrison C. Warren
    -------------------------------
    Morrison C. Warren

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