FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      
1. Name and Address of Reporting Person * LANKLER DOUGLAS M 2. Issuer Name and Ticker or Trading Symbol PFIZER INC [ PFE ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Executive Vice President
(Last)         (First)         (Middle)
PFIZER INC.-CORP. SECRETARY, 235 EAST 42ND ST.
3. Date of Earliest Transaction (MM/DD/YYYY)
11/26/2021
(Street)
NEW YORK, NY 10017
(City)       (State)       (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock  11/26/2021    S    124.0000  D $54.3200  106193.0000  D   
Common Stock  11/26/2021    S    909.0000  D $54.4500  105284.0000  D   
Common Stock  11/26/2021    S    1133.0000  D $54.2600  104151.0000  D   
Common Stock  11/26/2021    S    1497.0000  D $54.4700  102654.0000  D   
Common Stock  11/26/2021    S    1677.0000  D $54.4600  100977.0000  D   
Common Stock  11/26/2021    S    2736.0000  D $54.3900  98241.0000  D   
Common Stock  11/26/2021    S    4200.0000  D $54.5000  94041.0000  D   
Common Stock  11/26/2021    S    4500.0000  D $54.5500  89541.0000  D   
Common Stock  11/26/2021    S    5203.0000  D $54.1700  84338.0000  D   
Common Stock  11/26/2021    S    5765.0000  D $54.4000  78573.0000  D   
Common Stock  11/26/2021    S    5856.0000  D $54.3100  72717.0000  D   
Common Stock  11/26/2021    S    6400.0000  D $54.3000  66317.0000  D   
Common Stock                 1668.0000  I  By Rule 16b-3 Plan 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Explanation of Responses:

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
LANKLER DOUGLAS M
PFIZER INC.-CORP. SECRETARY
235 EAST 42ND ST.
NEW YORK, NY 10017


Executive Vice President

Signatures
Susan E. Grant, by power of atty., for Douglas M. Lankler 11/30/2021
**Signature of Reporting Person Date
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