AWS works with Pfizer to support more rapid
innovation and improved clinical manufacturing operations to help
develop tomorrow’s therapies
Today, Amazon Web Services, Inc. (AWS), an Amazon.com, Inc.
company (NASDAQ: AMZN), announced that it is working with Pfizer to
create innovative, cloud-based solutions with the potential to
improve how new medicines are developed, manufactured, and
distributed for testing in clinical trials. The companies are
exploring these advances through their newly created Pfizer Amazon
Collaboration Team (PACT) initiative, which applies AWS
capabilities in analytics, machine learning, compute, storage,
security, and cloud data warehousing to Pfizer laboratory, clinical
manufacturing, and clinical supply chain efforts. For instance, AWS
is helping Pfizer enhance its continuous clinical manufacturing
processes by incorporating predictive maintenance capabilities
built with AWS machine learning services like Amazon Lookout for
Equipment (AWS’s service for detecting abnormal equipment behavior
by analyzing sensor data). As a result, Pfizer can maximize uptime
for equipment such as centrifuges, agitators, pulverizers, coaters,
and air handlers used in clinical drug manufacturing. The overall
focus of this collaboration is to support Pfizer in more rapidly
and reliably producing new drugs and evaluating their potential
health benefit for patients.
“Our life sciences customers are increasingly looking for
opportunities to scale expertise, insight, and secure access to the
right information, at the right time, with the aim of reducing the
time and cost for drug development and clinical trials,” said
Kathrin Renz, Vice President of Business Development and Industries
at Amazon Web Services, Inc. “AWS’s breadth and depth of cloud
capabilities help support Pfizer’s teams through secure, novel
research methods as they work to optimize drug development and
clinical manufacturing processes. The past two years have
reinforced for the world just how much speed and agility matter at
every step of the research, development, and clinical manufacturing
cycle when lives are on the line. We’re proud to work with Pfizer
and lend our deep domain expertise to assist in developing
solutions that could significantly improve the lives of patients
globally.”
“Pfizer’s goal with AWS is to expedite the processes for drug
discovery and development in ways that can ultimately enhance
patient experiences and deliver new therapies to market. Working
closely with AWS experts in machine learning and analytics, we aim
to provide our scientists and researchers with the insights they
need to help deliver medical breakthroughs that change patients’
lives,” said Andrew McKillop, Vice President of Pharmaceutical
Sciences, Worldwide Research, Development, and Medical at
Pfizer.
AWS is working with Pfizer to develop a prototype solution for
detecting abnormal data points in its drug product continuous
clinical manufacturing platform for solid, oral-dose medicines. The
prototype solution uses Amazon SageMaker (AWS’s service for
building, training, and deploying machine learning models quickly
in the cloud and at the edge), Amazon Lookout for Equipment, Amazon
Lookout for Metrics (AWS’s service for automatically detecting
anomalies in metrics and identifying their root cause), and Amazon
QuickSight (AWS’s scalable machine learning-powered business
intelligence service for the cloud). The machine learning models
used in the prototype were able to provide early warnings for
alarms with minimal false positives and direct users to the
relevant signals. As a result, Pfizer can process data from the
equipment and sensors involved in Portable Continuous Miniature and
Modular (PCMM) manufacturing to detect anomalies as they occur,
predict maintenance needs, and reduce potential equipment
downtime.
Pfizer scientists will also collaborate with AWS healthcare and
life sciences professionals to explore how researchers in Pfizer’s
Pharmaceutical Sciences Small Molecules teams can extract and mine
information from legacy documents by leveraging AWS analytics and
machine learning services. Pfizer has an extensive collection of
documents that contain valuable data from a variety of drug
development processes. The documents include data related to
synthetic chemistry routes, recipes, analytical tests, method
development, formulation composition, clinical manufacturing
campaigns, batch records, technology transfer, and many other types
of work. Housed within these documents are potentially powerful
insights that could point Pfizer researchers in the right direction
for developing new drugs or repurposing existing ones—if the
researchers can identify and link the right information
efficiently. To gain quick, secure access to the right information
at the right time, Pfizer’s Pharmaceutical Sciences Small Molecules
teams are working with AWS to develop a prototype system that can
automatically extract, ingest, and process data from this
documentation to help in the design of lab experiments. The
prototype system is powered by Amazon Comprehend Medical (AWS’s
HIPAA-eligible natural language processing (NLP) service to extract
information from unstructured medical text accurately and quickly)
and Amazon SageMaker, and uses Amazon Cognito to deliver secure
user access control.
About Amazon Web Services
For over 15 years, Amazon Web Services has been the world’s most
comprehensive and broadly adopted cloud offering. AWS has been
continually expanding its services to support virtually any cloud
workload, and it now has more than 200 fully featured services for
compute, storage, databases, networking, analytics, machine
learning and artificial intelligence (AI), Internet of Things
(IoT), mobile, security, hybrid, virtual and augmented reality (VR
and AR), media, and application development, deployment, and
management from 81 Availability Zones within 25 geographic regions,
with announced plans for 27 more Availability Zones and nine more
AWS Regions in Australia, Canada, India, Indonesia, Israel, New
Zealand, Spain, Switzerland, and the United Arab Emirates. Millions
of customers—including the fastest-growing startups, largest
enterprises, and leading government agencies—trust AWS to power
their infrastructure, become more agile, and lower costs. To learn
more about AWS, visit aws.amazon.com.
About Amazon
Amazon is guided by four principles: customer obsession rather
than competitor focus, passion for invention, commitment to
operational excellence, and long-term thinking. Amazon strives to
be Earth’s Most Customer-Centric Company, Earth’s Best Employer,
and Earth’s Safest Place to Work. Customer reviews, 1-Click
shopping, personalized recommendations, Prime, Fulfillment by
Amazon, AWS, Kindle Direct Publishing, Kindle, Career Choice, Fire
tablets, Fire TV, Amazon Echo, Alexa, Just Walk Out technology,
Amazon Studios, and The Climate Pledge are some of the things
pioneered by Amazon. For more information, visit amazon.com/about
and follow @AmazonNews.
About Pfizer: Breakthroughs That Change Patients’
Lives
At Pfizer, we apply science and our global resources to bring
therapies to people that extend and significantly improve their
lives. We strive to set the standard for quality, safety and value
in the discovery, development and manufacture of health care
products, including innovative medicines and vaccines. Every day,
Pfizer colleagues work across developed and emerging markets to
advance wellness, prevention, treatments and cures that challenge
the most feared diseases of our time. Consistent with our
responsibility as one of the world's premier innovative
biopharmaceutical companies, we collaborate with health care
providers, governments and local communities to support and expand
access to reliable, affordable health care around the world. For
more than 170 years, we have worked to make a difference for all
who rely on us. We routinely post information that may be important
to investors on our website at www.Pfizer.com. In addition, to
learn more, please visit us on www.Pfizer.com and follow us on
Twitter at @Pfizer and @Pfizer News, LinkedIn, YouTube and like us
on Facebook at Facebook.com/Pfizer.
Pfizer Disclosure Notice: The information contained in
this release is as of November 29, 2021. Pfizer assumes no
obligation to update forward-looking statements contained in this
release as the result of new information or future events or
developments.
This release contains forward-looking information about an
initiative between Amazon Web Services, Inc. (AWS) and Pfizer (the
Pfizer Amazon Collaboration Team (PACT) initiative) that applies
AWS capabilities in analytics, machine learning, compute, storage,
security, and cloud data warehousing to Pfizer laboratory, clinical
manufacturing and clinical supply chain efforts, including efforts
by AWS and Pfizer to create innovative, cloud-based solutions with
the potential to improve how new medicines are developed,
manufactured, and distributed for testing in clinical trials,
including its potential benefits, that involve substantial risks
and uncertainties that could cause actual results to differ
materially from those expressed or implied by such statements.
Risks and uncertainties include, among other things, the
uncertainties inherent in research and development; uncertainties
regarding the commercial success of and the ability to realize the
anticipated benefits of the initiative; uncertainties regarding the
impact of COVID-19 on our business, operations and financial
results; other business effects, including the effects of industry,
market, economic, political or regulatory conditions; and
competitive developments.
A further description of risks and uncertainties can be found in
Pfizer’s Annual Report on Form 10-K for the fiscal year ended
December 31, 2020 and in its subsequent reports on Form 10-Q,
including in the sections thereof captioned “Risk Factors” and
“Forward-Looking Information and Factors That May Affect Future
Results,” as well as in its subsequent reports on Form 8-K, all of
which are filed with the U.S. Securities and Exchange Commission
and available at www.sec.gov and www.pfizer.com.
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