AMAM Ambrx Biopharma Inc

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-A/A

AMENDMENT NO. 1

FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES

PURSUANT TO SECTION 12(b) OR (g) OF THE

SECURITIES EXCHANGE ACT OF 1934

Securities to be registered pursuant to Section 12(b) of the Act:

If this form relates to the registration of a class of securities pursuant to Section 12(b) of the Exchange Act and is effective pursuant to General Instruction A.(c) or (e), please check the following box.  ☒

If this form relates to the registration of a class of securities pursuant to Section 12(g) of the Exchange Act and is effective pursuant to General Instruction A.(d) or (e), check the following box.  ☐

If this form relates to the registration of a class of securities concurrently with a Regulation A offering, check the following box.  ☐

Securities Act registration statement number to which this form relates: 333-256639.

Securities to be registered pursuant to Section 12(g) of the Act: None.

Explanatory Note

Ambrx Biopharma Inc. (the “Registrant”) previously filed a Registration Statement on Form 8-A on June 15, 2021 (the “Prior Form 8-A”) with the U.S. Securities and Exchange Commission (the “SEC”) with respect to the Registrant’s American depositary shares, each representing 7 ordinary shares, par value US $0.0001 per share (the “ADSs”), and the Registrant’s ordinary shares, par value US $0.0001 per share. This Amendment No. 1 to the Prior Form 8-A is being filed by the Registrant in connection with the transfer of the listing of the the ADSs from the New York Stock Exchange (“NYSE”) to the Nasdaq Global Select Market (“Nasdaq”). The transfer of the listing is scheduled to occur at the opening of trading on March 17, 2023. The ADSs are traded under the symbol “AMAM” on NYSE and have been approved for listing on Nasdaq under the symbol “AMAM.”

The description of the securities of the Registrant being registered is set forth under “Description of Share Capital” and “Description of American Depositary Shares” in the Registrant’s registration statement on Form F-3 (File No. 333-266404), originally filed with the SEC on July 29, 2022, as amended from time to time, under the Securities Act of 1933, as amended, which description is incorporated herein by reference.

Pursuant to the Instructions as to exhibits with respect to Form 8-A, no exhibits are required to be filed because no other securities of the Registrant are registered on Nasdaq and the securities registered hereby are not being registered pursuant to Section 12(g) of the Securities Exchange Act of 1934, as amended.

SIGNATURE

Pursuant to the requirements of Section 12 of the Securities Exchange Act of 1934, the Registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereto duly authorized.