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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):June 28, 2023
JAGUAR HEALTH, INC.
(Exact name of registrant as specified in its charter)
Delaware |
001-36714 |
46-2956775 |
(State or other jurisdiction of incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
200 Pine Street, Suite 400
San Francisco, California |
94104 |
(Address of principal executive offices) |
(Zip Code) |
Registrant’s telephone number, including
area code: (415) 371-8300
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):
¨ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
¨ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
¨ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
¨ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).
Emerging growth company ¨
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨
Title of each class |
Trading Symbol(s) |
Name of each exchange on which registered |
Common Stock, Par Value $0.0001 Per Share |
JAGX |
The Nasdaq Capital Market |
Item 1.01 Entry into a Material Definitive
Agreement.
Exchange Transaction
As previously disclosed, (i) on December 22,
2020, Jaguar Health, Inc. (the “Company”) sold to Uptown Capital, LLC (f/k/a Irving Park Capital, LLC; “Uptown”)
a royalty interest (as amended, the “December 2020 Royalty Interest”) entitling Uptown to $12 million of future royalties
on sales of Mytesi (crofelemer) and certain up-front license fees and milestone payments from licensees and/or distributors for an aggregate
purchase price of $6 million; (ii) on March 8, 2021, the Company sold to Streeterville Capital, LLC (“Streeterville”)
a royalty interest (as amended, the “March 2021 Royalty Interest”) entitling Streeterville to $10 million of future royalties
on sales of Mytesi (crofelemer) for the prophylaxis and/or symptomatic relief of inflammatory diarrhea and certain up-front license fees
and milestone payments from licensees and/or distributors for an aggregate purchase price of $5 million; and (iii) on August 24,
2022, the Company sold to Streeterville a royalty interest (as amended, the “August 2022 Royalty Interest”) entitling
Streeterville to receive $12 million of future royalties on sales of Mytesi (crofelemer) for any indications that could cannibalize crofelemer
indications or any other chronic indication and certain up-front license fees and milestone payments from licensees and/or distributors
for an aggregate purchase price of $4 million.
On June 28, 2023, the Company entered into
(i) a privately negotiated exchange agreement with Uptown (the “Uptown Exchange Agreement”), pursuant to which the Company
issued an aggregate of 32 shares of the Company’s newly authorized Series H Convertible Preferred Stock (the “Series H
Preferred Stock”) to Uptown, at an effective exchange price per share equal to the market price (defined as the Minimum Price under
Nasdaq Listing Rule 5635(d)) as of the date of the Uptown Exchange Agreement, in exchange for a $756,992.00 reduction in the outstanding
balance of the December 2020 Royalty Interest, and (ii) a privately negotiated exchange agreement with Streeterville (the “Streeterville
Exchange Agreement;” together with the Uptown Exchange Agreement, the “Exchange Agreement”), pursuant to which the Company
issued an aggregate of 73 shares of Series H Convertible Preferred Stock to Streeterville, at an effective exchange price per share
equal to the market price as of the date of the Streeterville Exchange Agreement, in exchange for a $1,726,888 reduction in the outstanding
balance of the August 2022 Royalty Interest (collectively, the “Exchange Transaction”).
Subject to the terms of the Series H Preferred
Stock, each share of Series H Preferred Stock is convertible into shares of common stock, par value $0.0001 per share (“Common
Stock”) of the Company (the “Conversion Shares”). The terms of the Series H Preferred Stock are set forth in a
Certificate of Designation of Preferences, Rights and Limitations of Series H Convertible Preferred Stock (the “Certificate
of Designation”) filed with the Secretary of State of Delaware and effective on June 28, 2023. A description of the terms of
the Series H Preferred Stock is included under Item 5.03 of this Current Report and is incorporated herein by reference. The shares
of Series H Preferred Stock and Conversion Shares are subject to the Standstill (as defined below) and may not be sold during the
Standstill Period (as defined in the Standstill Agreement referenced below).
The Exchange Agreement includes representations,
warranties, and covenants customary for a transaction of this type.
The foregoing summary of the Exchange Agreement
does not purport to be complete and is subject to, and qualified in its entirety by the Exchange Agreement, the form of which is attached
as Exhibit 10.1 to this Current Report on Form 8-K and is incorporated herein by reference.
Amendment to Standstill Agreement
As previously disclosed, on May 8, 2023,
the Company and Napo Pharmaceuticals, Inc., a wholly-owned subsidiary of the Company (“Napo”), entered into a standstill
agreement (the “Standstill Agreement”) with Iliad Research and Trading, L.P. (“Iliad”), Uptown, and Streeterville
(together with Iliad and Uptown, “Investor”) with respect to four outstanding royalty interests issued by the Company to Investor,
including the December 2020 Royalty Interest, March 2021 Royalty Interest, August 2022 Royalty Interest, and a fourth royalty
interest dated October 8, 2020 (collectively, the “Royalty Interests”). The Standstill Agreement provides that during
the Standstill Period (as defined in the Standstill Agreement), (a) the Company may refrain from making royalty payments owed pursuant
to the terms of the Royalty Interests, and (b) Investor will refrain from buying, selling, or otherwise trading in the Company’s
Common Stock (collectively, the “Standstill”). Except for certain types of Exempt Issuance as specified in the Standstill
Agreement, any offering or sale of any debt or equity securities (or instruments convertible into equity securities) of the Company will
trigger the termination of the Standstill Period.
On June 28, 2023, the Company and Napo entered
into the first amendment to the Standstill Agreement (the “First Amendment”). The First Amendment amends the Standstill Agreement
to, among other things, permit (i) the Company to consummate the Exchange Transaction without triggering the termination of the Standstill
Period, and (ii) Investor to (A) consummate the Exchange Transaction during the Standstill Period and (B) sell all shares
of Common Stock beneficially owned by Investor immediately prior to the consummation of the Exchange Transaction during the Standstill
Period.
The foregoing descriptions of the Royalty Interests
are not complete and are qualified in their entirety by reference to the Royalty Interests, which are filed as exhibits to our Current
Reports on Form 8-K filed with the Securities and Exchange Commission (the “SEC”) on October 9, 2020, December 29,
2020, March 11, 2021 and August 30, 2022, and the global amendment thereto as described in our Current Report on Form 8-K
filed with the SEC on October 21, 2022.
The foregoing summary of the First Amendment to
the Standstill Agreement does not purport to be complete and is subject to, and qualified in its entirety by the First Amendment to the
Standstill Agreement, which is attached as Exhibit 10.2 to this Current Report on Form 8-K and is incorporated herein by reference.
Item 3.02 Unregistered Sales of Equity Securities.
The information contained above in Item 1.01 is
hereby incorporated by reference into this Item 3.02 in its entirety. The Series H Preferred Shares were issued in reliance on the
exemption from registration provided under Section 3(a)(9) of the Securities Act of 1933, as amended.
Item 5.03 Amendments
to Articles of Incorporation or Bylaws; Change in Fiscal Year.
Series H Certificate of Designation
As disclosed under Items 1.01 and 3.02 above,
in connection with the Exchange Transaction, the Company agreed to issue shares of Series H Preferred Stock to Uptown and Streeterville.
The preferences, rights, limitations and other matters relating to the Series H Preferred Stock are set forth in the Certificate
of Designation. The shares of Series H Preferred Stock rank pari passu with shares of the Common Stock as to distributions of assets
upon liquidation, dissolution or winding up of the Company. The Certificate of Designation is filed as Exhibit 3.1 to this Current
Report on Form 8-K.
The Certificate of Designation authorizes the
Company to issue 105 of its 4,475,074 authorized shares of preferred stock as Series H Preferred Stock. The original issue price
for the Series H Preferred Stock is $23,656 per share, subject to appropriate adjustment in the event of any stock dividend, stock
split, combination or other similar recapitalization with respect to the Series H Preferred Stock.
The following is a summary of the principal terms
of the Series H Preferred Stock as set forth in the Certificate of Designation:
Dividends
Holders of shares of Series H Preferred Stock
will be entitled to receive dividends equal, on an as-if-converted to shares of Common Stock basis, to and in the same form as dividends
actually paid on shares of the Common Stock when, as, and if such dividends are paid on shares of the Common Stock.
Voting Rights
The Series H Preferred Stock shall have no
voting rights. As long as any shares of Series H Preferred Stock are outstanding, the Company shall not, without the affirmative
vote of the holders of a majority of the then outstanding shares of the Series H Preferred Stock, (a) alter or change adversely
the powers, preferences or rights given to the Series H Preferred Stock or alter or amend the Certificate of Designation or (b) enter
into any agreement with respect to any of the foregoing.
Liquidation Rights
In the event of any voluntary or involuntary liquidation,
dissolution or winding up of the Company (each, a “Liquidation Event”), the holders of shares of Series H Preferred Stock
will be entitled to receive out of the assets of the Company the same amount that a holder of shares of the Common Stock would receive
if the shares of Series H Preferred Stock were fully converted to Common Stock, which amounts shall be paid pari passu with all holders
of Common Stock.
Conversion
Subject to the Beneficial Ownership Limitation
(as defined below), each share of Series H Preferred Stock is convertible into 50,000 shares of Common Stock (quotient obtained from
dividing the $23,656.00 stated value of each share of Series H Preferred Stock by a conversion price of $0.47312), which conversion
ratio is subject to adjustment for subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations and
other similar transactions of the Common Stock.
In addition, the Company shall not effect any
conversion of the Series H Preferred Stock, and a holder thereof shall not have the right to convert any portion of the Series H
Preferred Stock, to the extent that, after giving effect to the conversion set forth on the applicable Notice of Conversion, such holder
(together with such holder’s Affiliates and Attribution Parties (both as defined in the Certificate of Designation)) would beneficially
own in excess of the Beneficial Ownership Limitation. The “Beneficial Ownership Limitation” shall be 9.99% of the number of
shares of Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock issuable upon conversion
of the Series H Preferred Stock held by the applicable holder. A holder, upon notice to the Company, may increase or decrease the
Beneficial Ownership Limitation provisions in the Certificate of Designation applicable to its Series H Preferred Stock provided
that the Beneficial Ownership Limitation in no event exceeds 9.99% of the number of shares of the Common Stock outstanding immediately
after giving effect to the issuance of shares of Common Stock upon conversion of the Series H Preferred Stock held by the holder
and the relevant provisions of the Certificate of Designation shall continue to apply.
Trading Market
There is no established trading market for any
of the Series H Preferred Stock, and we do not expect a market to develop. We do not intend to apply for a listing for any of the
Series H Preferred Stock on any securities exchange or other nationally recognized trading system. Without an active trading market,
the liquidity of the Series H Preferred Stock will be limited.
The foregoing description of the Certificate of
Designation does not purport to be complete and is qualified in its entirety by reference to the full text of the Certificate of Designation,
a copy of which is filed as Exhibit 3.1 to this Current Report and is incorporated by reference herein.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibit
Exhibit
No. |
|
Description |
3.1 |
|
Certificate
of Designation of Preferences, Rights and Limitations of Series H Convertible Preferred Stock. |
10.1 |
|
Form of
Exchange Agreement. |
10.2 |
|
First
Amendment to the Standstill Agreement, dated June 28, 2023, by and among Jaguar Health, Inc., Napo Pharmaceuticals, Inc., Iliad
Research and Trading, L.P., Uptown Capital, LLC and Streeterville Capital, LLC. |
104 |
|
Cover Page Interactive Data File (embedded within the inline XBRL document) |
SIGNATURES
Pursuant to the requirements
of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned
hereunto duly authorized.
| JAGUAR
HEALTH, INC. |
| |
| By: |
/s/ Lisa
A. Conte |
| Name: |
Lisa
A. Conte |
| Title: |
Chief
Executive Officer & President |
Date: July 3, 2023 | |
Exhibit 3.1
JAGUAR HEALTH, INC.
CERTIFICATE OF DESIGNATION OF PREFERENCES,
RIGHTS AND LIMITATIONS
OF
SERIES H CONVERTIBLE
PREFERRED STOCK
Pursuant to Section 151 of the
General Corporation Law of the State of Delaware
The undersigned, Lisa A. Conte and Carol R. Lizak,
do hereby certify that:
1. They
are the Chief Executive Officer/President and Chief Financial Officer, respectively, of Jaguar Health, Inc., a Delaware corporation
(the “Corporation”).
2. The
following resolutions were duly adopted by the board of directors of the Corporation (the “Board of Directors”):
WHEREAS, the certificate of
incorporation of the Corporation provides for a class of its authorized stock known as preferred stock, consisting of 4,475,074 shares,
$0.0001 par value per share, issuable from time to time in one or more series, of which 137 shares designated as Series G Convertible
Preferred Stock (the “Series G Preferred Stock”) are issued and outstanding as of the date hereof;
WHEREAS, the Board of Directors
is authorized to fix the dividend rights, dividend rate, voting rights, conversion rights, rights and terms of redemption and liquidation
preferences of any wholly unissued series of preferred stock and the number of shares constituting any series and the designation thereof,
of any of them; and
WHEREAS, it is the desire
of the Board of Directors, pursuant to its authority as aforesaid, to fix the rights, preferences, restrictions and other matters relating
to a series of the preferred stock, which shall consist of 105 shares of the preferred stock which the Corporation has the authority to
issue, as follows:
NOW, THEREFORE, BE IT RESOLVED,
that the Board of Directors does hereby provide for the issuance of a series of preferred stock for cash or exchange of other securities,
rights, powers, property, or other lawful consideration and does hereby fix and determine the rights, preferences, restrictions and other
matters relating to such series of preferred stock as follows:
TERMS OF Series H
CONVERTIBLE PREFERRED STOCK
Section 1. Definitions.
For the purposes hereof, the following terms shall have the following meanings:
“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control
with a Person, as such terms are used in and construed under Rule 405 of the Securities Act.
“Attribution
Parties” shall have the meaning set forth in Section 6(d).
“Beneficial
Ownership Limitation” shall have the meaning set forth in Section 6(d).
“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or any day
on which banking institutions in the State of New York are authorized or required by law or other governmental action to close.
“Buy-In”
shall have the meaning set forth in Section 6(c)(iv).
“Commission”
means the United States Securities and Exchange Commission.
“Common
Stock” means the Corporation’s common stock, par value $0.0001 per share, and stock of any other class of securities into
which such securities may hereafter be reclassified or changed.
“Common
Stock Equivalents” means any securities of the Corporation or the Subsidiaries which would entitle the holder thereof to
acquire at any time Common Stock, including, without limitation, any debt, preferred stock, rights, options, warrants or other
instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to
receive, Common Stock.
“Company
Conversion Notice” means a notice delivered by the Corporation to effect a Mandatory Conversion of all the outstanding Series H
Preferred Stock, provided that the effective date of such Mandatory Conversion shall be no less than ten (10) Business Days following
the date that such notice is deemed to have been given.
“Conversion
Date” shall have the meaning set forth in Section 6(a).
“Conversion
Price” for each share of Series H Preferred Stock shall be, unless otherwise provided in this Certificate of Designation,
equal to $0.47312, subject to adjustment for reverse and forward stock splits, stock dividends, stock combinations and other similar transactions
of the Common Stock that occur after the Original Issue Date as set forth in Section 7 hereof.
“Conversion
Ratio” for each share of Series H Preferred Stock shall be equal to the Stated Value divided by the applicable Conversion
Price.
“Conversion
Shares” means, collectively, the shares of Common Stock issuable upon conversion of the shares of Series H Preferred Stock
in accordance with the terms hereof.
“Delaware
Courts” shall have the meaning set forth in Section 8(b).
“Dividend Shares”
shall have the meaning given such term in Section 3.
“Fundamental Transaction”
shall have the meaning set forth in Section 7(d).
“Holder”
shall have the meaning given such term in Section 2.
“Liquidation
Event” shall have the meaning set forth in Section 5.
“Mandatory
Conversion” shall have the meaning set forth in Section 6(b).
“Mandatory
Conversion Date” shall have the meaning set forth in Section 6(b).
“Mandatory
Conversion Determination” shall have the meaning set forth in Section 6(b).
“Notice
of Conversion” shall have the meaning set forth in Section 6(a).
“Original
Issue Date” means the date of the first issuance of any shares of the Series H Preferred Stock regardless of the number
of transfers of any particular shares of Series H Preferred Stock.
“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company,
joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.
“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.
“Series H
Preferred Stock” shall have the meaning set forth in Section 2.
“Share
Delivery Date” shall have the meaning set forth in Section 6(c)(i).
“Stated
Value” means $23,656.00.
“Trading
Day” means a day on which the principal Trading Market is open for business.
“Trading
Market” means any of the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date
in question: the NYSE American, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, or the New York
Stock Exchange (or any successors to any of the foregoing).
“Transfer
Agent” means American Stock Transfer & Trust Company, the current transfer agent of the Corporation with a mailing
address of 59 Maiden Lane, New York, New York and a facsimile number of 718-236-4588, and any successor transfer agent of the Corporation.
Section 2. Designation,
Amount and Par Value. This series of preferred stock shall be designated as Series H Convertible
Preferred Stock (the “Series H Preferred Stock”) and the number of shares so designated shall be 105 (One Hundred
Five) (each holder of the Series H Preferred Stock a “Holder” and collectively, the “Holders”).
Each share of Series H Preferred Stock shall have a par value of $0.0001 per share. The Series H Preferred Stock will initially
be issued in book-entry form.
Section 3. Dividends.
Holders of shares of Series H Preferred Stock will be entitled to receive dividends equal, on an as-if-converted to shares of Common
Stock basis, to and in the same form as dividends actually paid on shares of the Common Stock when, as, and if such dividends are paid
on shares of the Common Stock. The dividends shall be paid (to the extent accrued and not previously paid) upon the Mandatory Conversion
Date. Notwithstanding the foregoing, to the extent that a Holder’s right to participate in any stock dividend declared on the Common
Stock to which such Holder is entitled to (“Dividend Shares”) would result in such Holder exceeding the Beneficial
Ownership Limitation, then such Holder shall not be entitled to participate in any such dividend to such extent (or in the beneficial
ownership of any Dividend Shares as a result of such dividend to such extent) and the portion of such Dividend Shares that would cause
such Holder to exceed the Beneficial Ownership Limitation shall be held by the Corporation in abeyance for the benefit of such Holder
(which shall not give the Holder any power to vote or dispose of such Dividend Shares) until such time, if ever, as such Holder’s
beneficial ownership thereof would not result in such Holder exceeding the Beneficial Ownership Limitation.
Section 4. Voting
Rights. Except as otherwise provided herein or as otherwise required by law, the Series H
Preferred Stock shall have no voting rights. In addition, as long as any shares of Series H Preferred Stock are outstanding, the
Corporation shall not, without the affirmative vote of the Holders of a majority of the then outstanding shares of the Series H Preferred
Stock, (a) alter or change adversely the powers, preferences or rights given to the Series H Preferred Stock or alter or amend
this Certificate of Designation or (b) enter into any agreement with respect to any of the foregoing.
Section 5. Liquidation
Event. Upon any liquidation, dissolution or winding-up of the Corporation, whether voluntary
or involuntary (each, a “Liquidation Event”), the Holders shall be entitled to receive out of the assets, whether capital
or surplus, of the Corporation the same amount that a holder of shares of the Common Stock would receive if the shares of Series H
Preferred Stock were fully converted (disregarding for such purposes any conversion limitations hereunder) to Common Stock, which amounts
shall be paid pari passu with all holders of Common Stock. The Corporation shall mail written notice of any such Liquidation Event,
not less than thirty (30) days prior to the payment date stated therein, to each Holder.
Section 6. Conversion.
(a) Conversions
at Option of Holder. Subject to Section 6(d) (Beneficial Ownership Limitation), each share of Series H
Preferred Stock shall be convertible, at any time and from time to time on or after the Original Issue Date, at the option of the Holder
thereof, into that number of shares of Common Stock determined by multiplying (i) the number of shares of Series H Preferred
Stock to be converted as set forth in the applicable Notice of Conversion (as defined below) by (ii) the Conversion Ratio. Holders
shall effect conversions by providing the Corporation with the form of conversion notice attached hereto as Annex A (a “Notice
of Conversion”). Each Notice of Conversion shall specify the number of shares of Series H Preferred Stock to be converted,
the number of shares of Series H Preferred Stock owned prior to the conversion at issue, the number of shares of Series H Preferred
Stock owned subsequent to the conversion at issue and the date on which such conversion is to be effected, which date may not be prior
to the date the applicable Holder delivers by facsimile or other method specified hereunder such Notice of Conversion to the Corporation
(such date, the “Optional Conversion Date”). If no Optional Conversion Date is specified in a Notice of Conversion,
the Optional Conversion Date shall be the date that such Notice of Conversion to the Corporation is deemed delivered hereunder. No ink-original
Notice of Conversion shall be required, nor shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of
Conversion form be required.
(b) Mandatory
Conversion. On the tenth (10) anniversary of the Original Issue Date (the “Mandatory Conversion Date”
and together with an Optional Conversion Date, the “Conversion Date”), each outstanding share of Series H
Preferred Stock will automatically convert (subject to the Beneficial Ownership Limitation set forth in Section 6(d))
into such number of fully paid and non-assessable shares of Common Stock as is determined by dividing the Stated Value by the
Conversion Price in effect on the Mandatory Conversion Date (a “Mandatory Conversion”). Within two Trading Days
of the Mandatory Conversion Date, the Corporation shall deliver to each Holder the Conversion Shares issuable upon conversion
of such Holder’s Series H Preferred Stock as of the Mandatory Conversion Date. To the extent that the Beneficial
Ownership Limitation contained in Section 6(d) applies to any Holder, such Holder shall within five Business Days
of such Holder’s receipt of the Company Conversion Notice, provide the Corporation with a written determination (a
“Mandatory Conversion Determination”), of whether such Holder’s Series H Preferred Stock is
convertible (in relation to other securities owned by such Holder together with any Affiliates and Attribution Parties) and of how
many shares of Series H Preferred Stock are convertible, and the submission of a Mandatory Conversion Determination shall be
deemed to be such Holder’s determination of the maximum number of shares of Series H Preferred Stock that may be
converted, subject to the Beneficial Ownership Limitation and the portion of the shares of Common Stock issuable upon such Mandatory
Conversion hereunder that would cause such Holder to exceed the Beneficial Ownership Limitation shall be held by the Corporation in
abeyance for the benefit of such Holder (which shall not give the Holder any power to vote or dispose of such shares) until such
time, if ever, as such Holder’s beneficial ownership thereof would not result in such Holder exceeding the Beneficial
Ownership Limitation. To ensure compliance with this restriction, each Holder will be deemed to represent to the Corporation each
time it delivers a Mandatory Conversion Determination that such determination has not violated the restrictions set forth in Section 6(d) and
the Corporation shall have no obligation to verify or confirm the accuracy of such determination.
(c) Mechanics
of Conversion
(i) Delivery
of Conversion Shares Upon Conversion. Not later than the earlier of (i) two (2) Trading Days and (ii) the number of
Trading Days comprising the Standard Settlement Period (as defined below) after each Conversion Date (the “Share Delivery Date”),
the Corporation shall deliver, or cause to be delivered, to the converting Holder the Conversion Shares to be issued upon the conversion
of the number of shares of Series H Preferred Stock to be converted pursuant to Section 6(a) or 6(b), as
applicable. When delivering the Conversion Shares as provided herein, the Corporation shall use commercially reasonable efforts to deliver
the Conversion Shares required to be delivered by the Corporation under this Section 6 through the Transfer Agent. As used
herein, “Standard Settlement Period” means the standard settlement period, expressed in a number of Trading Days, on
the Corporation’s primary Trading Market with respect to the Common Stock as in effect on the date of delivery of the Notice of
Conversion.
(ii) Failure
to Deliver Conversion Shares. If, in the case of any Notice of Conversion, such Conversion Shares are not delivered to or as directed
by the applicable Holder by the Share Delivery Date, the Holder shall be entitled to elect by written notice to the Corporation at any
time on or before its receipt of such Conversion Shares, to rescind such Conversion, in which event the Corporation shall promptly return
to the Holder the shares of Series H Preferred Stock that were the subject of such Notice of Conversion and the Holder shall promptly
return to the Corporation the Conversion Shares issued to such Holder pursuant to the rescinded Notice of Conversion.
(iii) Obligation
Absolute; Partial Liquidated Damages. The Corporation’s obligation to issue and deliver the Conversion Shares upon conversion
of Series H Preferred Stock in accordance with the terms hereof are absolute and unconditional, irrespective of any action or inaction
by a Holder to enforce the same, any waiver or consent with respect to any provision hereof, the recovery of any judgment against any
Person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach or alleged
breach by such Holder or any other Person of any obligation to the Corporation or any violation or alleged violation of law by such Holder
or any other person, and irrespective of any other circumstance which might otherwise limit such obligation of the Corporation to such
Holder in connection with the issuance of such Conversion Shares; provided, however, that such delivery shall not operate
as a waiver by the Corporation of any such action that the Corporation may have against such Holder. Nothing herein shall limit a Holder’s
right to pursue actual damages for the Corporation’s failure to deliver Conversion Shares within the period specified herein and
such Holder shall have the right to pursue all remedies available to it hereunder, at law or in equity including, without limitation,
a decree of specific performance, injunctive relief, or both specific performance and injunctive relief. The exercise of any such rights
shall not prohibit a Holder from seeking to enforce damages pursuant to any other Section hereof or under applicable law.
(iv) Compensation
for Buy-In on Failure to Timely Deliver Conversion Shares Upon Conversion. In addition to any other rights available to the
Holder, if the Corporation fails for any reason to deliver to a Holder the applicable Conversion Shares by the Share Delivery Date
pursuant to Section 6(c)(i), and if after such Share Delivery Date such Holder is required by its brokerage firm to
purchase (in an open market transaction or otherwise), or the Holder’s brokerage firm otherwise purchases, shares of
Common Stock to deliver in satisfaction of a sale by such Holder of the Conversion Shares which such Holder was entitled to receive
upon the conversion relating to such Share Delivery Date (a “Buy-In”), then the Corporation shall (A) pay in
cash to such Holder (in addition to any other remedies available to or elected by such Holder) the amount, if any, by which
(x) such Holder’s total purchase price (including any brokerage commissions) for the Common Stock so purchased exceeds
(y) the product of (1) the aggregate number of shares of Common Stock that such Holder was entitled to receive from the
conversion at issue multiplied by (2) the actual sale price at which the sell order giving rise to such purchase obligation was
executed (including any brokerage commissions) and (B) at the option of such Holder, either reissue (if surrendered) the shares
of Series H Preferred Stock equal to the number of shares of Series H Preferred Stock submitted for conversion (in which
case, such conversion shall be deemed rescinded) or deliver to such Holder the number of shares of Common Stock that would have been
issued if the Corporation had timely complied with its delivery requirements under Section 6(c)(i). For example, if a
Holder purchases shares of Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect to an attempted
conversion of shares of Series H Preferred Stock with respect to which the actual sale price of the Conversion Shares
(including any brokerage commissions) giving rise to such purchase obligation was a total of $10,000 under clause (A) of the
immediately preceding sentence, the Corporation shall be required to pay such Holder $1,000. The Holder shall provide the
Corporation written notice indicating the amounts payable to such Holder in respect of the Buy-In and, upon request of the
Corporation, evidence of the amount of such loss. Nothing herein shall limit a Holder’s right to pursue any other remedies
available to it hereunder, at law or in equity including, without limitation, a decree of specific performance and/or injunctive
relief with respect to the Corporation’s failure to timely deliver Conversion Shares upon conversion of the shares of
Series H Preferred Stock as required pursuant to the terms hereof.
(v) Reservation
of Shares Issuable Upon Conversion. The Corporation covenants that it will at all times reserve and keep available out of its authorized
and unissued shares of Common Stock for the sole purpose of issuance upon conversion of the Series H Preferred Stock as herein provided,
free from preemptive rights or any other actual contingent purchase rights of Persons other than the Holder (and the other holders of
the Series H Preferred Stock), not less than such aggregate number of shares of the Common Stock as shall be issuable (taking into
account the adjustments and restrictions of Section 7) upon the conversion of the then outstanding shares of Series H
Preferred Stock. The Corporation covenants that all shares of Common Stock that shall be so issuable shall, upon issue, be duly authorized,
validly issued, fully paid and nonassessable.
(vi) Fractional
Shares. No fractional shares or scrip representing fractional shares shall be issued upon the conversion of the Series H Preferred
Stock. As to any fraction of a share which the Holder would otherwise be entitled to receive upon such conversion, the Corporation shall
at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the
fair market value of a share of Common Stock as determined in good faith by the Board of Directors of the Corporation, or round up to
the next whole share. Notwithstanding anything to the contrary contained herein, but consistent with the provisions of this subsection
with respect to fractional Conversion Shares, nothing shall prevent any Holder from converting fractional shares of Series H Preferred
Stock.
(vii) Transfer
Taxes and Expenses. The issuance of Conversion Shares on conversion of this Series H Preferred Stock shall be made without charge
to any Holder for any documentary stamp or similar taxes that may be payable in respect of the issue or delivery of such Conversion Shares,
provided that the Corporation shall not be required to pay any tax that may be payable in respect of any transfer involved in the issuance
and delivery of any such Conversion Shares upon conversion in a name other than that of the Holders of such shares of Series H Preferred
Stock and the Corporation shall not be required to issue or deliver such Conversion Shares unless or until the Person or Persons requesting
the issuance thereof shall have paid to the Corporation the amount of such tax or shall have established to the satisfaction of the Corporation
that such tax has been paid. The Corporation shall pay all Transfer Agent fees required for same-day processing of any Notice of Conversion
and all fees to the Depository Trust Company (or another established clearing corporation performing similar functions) required for same-day
electronic delivery of the Conversion Shares.
(d) Beneficial
Ownership Limitation. The Corporation shall not effect any conversion of the Series H Preferred Stock, including, without
limitation, a Mandatory Conversion, and a Holder shall not have the right to receive dividends hereunder or convert any portion of
the Series H Preferred Stock, to the extent that, after giving effect to the receipt of Dividend Shares hereunder or
conversion set forth on the applicable Notice of Conversion, to the extent that, after giving effect to the conversion set forth on
the applicable Notice of Conversion, such Holder (together with such Holder’s Affiliates, and any Persons acting as a group
together with such Holder or any of such Holder’s Affiliates (such Persons, “Attribution Parties”)) would
beneficially own in excess of the Beneficial Ownership Limitation (as defined below). For purposes of the foregoing sentence, the
number of shares of Common Stock beneficially owned by such Holder and its Affiliates and Attribution Parties shall include the
number of shares of Common Stock received as Dividend Shares or issuable upon conversion of the Series H Preferred Stock with
respect to which such determination is being made, but shall exclude the number of shares of Common Stock which are issuable upon
(i) conversion of the remaining, unconverted Series H Preferred Stock beneficially owned by such Holder or any of its
Affiliates or Attribution Parties and (ii) exercise or conversion of the unexercised or unconverted portion of any other
securities of the Corporation subject to a limitation on conversion or exercise analogous to the limitation contained herein
beneficially owned by such Holder or any of its Affiliates or Attribution Parties. Except as set forth in the preceding sentence,
for purposes of this Section 6(d), beneficial ownership shall be calculated in accordance with
Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. To the extent that the
limitation contained in this Section 6(d) applies, the determination of whether the Series H Preferred Stock
is convertible (in relation to other securities owned by such Holder together with any Affiliates and Attribution Parties) and of
how many shares of the Series H Preferred Stock are convertible shall be in the sole discretion of such Holder, and the
submission of a Notice of Conversion shall be deemed to be such Holder’s determination of whether the shares of Series H
Preferred Stock may be converted (in relation to other securities owned by such Holder together with any Affiliates and Attribution
Parties) and how many shares of the Series H Preferred Stock are convertible, in each case subject to the Beneficial Ownership
Limitation. To ensure compliance with this restriction, each Holder will be deemed to represent to the Corporation each time it
delivers a Notice of Conversion that such Notice of Conversion has not violated the restrictions set forth in this paragraph and the
Corporation shall have no obligation to verify or confirm the accuracy of such determination. In addition, a determination as to any
group status as contemplated above shall be determined in accordance with Section 13(d) of the Exchange Act and the
rules and regulations promulgated thereunder. For purposes of this Section 6(d), in determining the number of
outstanding shares of Common Stock, a Holder may rely on the number of outstanding shares of Common Stock as stated in the most
recent of the following: (i) the Corporation’s most recent periodic or annual report filed with the Commission, as the
case may be, (ii) a more recent public announcement by the Corporation or (iii) a more recent written notice by the
Corporation or the Transfer Agent setting forth the number of shares of Common Stock outstanding. Upon the written or oral request
(which may be via email) of a Holder, the Corporation shall within two Trading Days confirm orally and in writing to such Holder the
number of shares of Common Stock then outstanding. In any case, the number of outstanding shares of Common Stock shall be determined
after giving effect to the conversion or exercise of securities of the Corporation, including the Series H Preferred Stock, by
such Holder or its Affiliates or Attribution Parties since the date as of which such number of outstanding shares of Common Stock
was reported. The “Beneficial Ownership Limitation” shall be 9.99% of the number of shares of the Common Stock
outstanding immediately after giving effect to the issuance of shares of Common Stock issuable upon conversion of the Series H
Preferred Stock held by the applicable Holder. A Holder, upon notice to the Corporation, may increase or decrease the Beneficial
Ownership Limitation provisions of this Section 6(d) applicable to its Series H Preferred Stock provided that
the Beneficial Ownership Limitation in no event exceeds 9.99% of the number of shares of the Common Stock outstanding immediately
after giving effect to the issuance of shares of Common Stock upon conversion of the Series H Preferred Stock held by the
Holder and the provisions of this Section 6(d) shall continue to apply. Any such increase in the Beneficial
Ownership Limitation will not be effective until the 61st day after such notice is delivered to the Corporation and shall only apply
to such Holder and no other Holder. The provisions of this paragraph shall be construed and implemented in a manner otherwise than
in strict conformity with the terms of this Section 6(d) to correct this paragraph (or any portion hereof) which
may be defective or inconsistent with the intended Beneficial Ownership Limitation contained herein or to make changes or
supplements necessary or desirable to properly give effect to such limitation. The limitations contained in this paragraph shall
apply to a successor holder of the Series H Preferred Stock.
Section 7. Certain
Adjustments.
(a) Stock
Dividends and Stock Splits. If the Corporation, at any time while this Series H Preferred Stock is outstanding:
(i) pays a stock dividend or otherwise makes a distribution or distributions payable in shares of Common Stock on shares of
Common Stock or any other Common Stock Equivalents (which, for avoidance of doubt, shall not include any shares of Common Stock
issued by the Corporation upon conversion of, or payment of a dividend on, this Series H Preferred Stock), (ii) subdivides outstanding
shares of Common Stock into a larger number of shares, (iii) combines (including by way of a reverse stock split) outstanding
shares of Common Stock into a smaller number of shares, or (iv) issues, in the event of a reclassification of shares of the
Common Stock, any shares of capital stock of the Corporation, then the Conversion Price shall be multiplied by a fraction of which
the numerator shall be the number of shares of Common Stock (excluding any treasury shares of the Corporation) outstanding
immediately before such event, and of which the denominator shall be the number of shares of Common Stock outstanding immediately
after such event. Any adjustment made pursuant to this Section 7(a) shall become effective immediately after the
record date for the determination of stockholders entitled to receive such dividend or distribution and shall become effective
immediately after the effective date in the case of a subdivision, combination or re-classification.
(b) Subsequent
Rights Offerings. In addition to any adjustments pursuant to Section 7(a) above, if at any time the Corporation grants,
issues or sells any Common Stock Equivalents or rights to purchase stock, warrants, securities or other property pro rata to the record
holders of shares of Common Stock (the “Purchase Rights”), then the Holder will be entitled to acquire, upon the terms
applicable to such Purchase Rights, the aggregate Purchase Rights which the Holder could have acquired if the Holder had held the number
of shares of Common Stock acquirable upon complete conversion of such Holder’s Series H Preferred Stock (without regard to
any limitations on conversion hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date on
which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the date as of which
the record holders of shares of Common Stock are to be determined for the grant, issue or sale of such Purchase Rights (provided, however,
to the extent that the Holder’s right to participate in any such Purchase Right would result in the Holder exceeding the Beneficial
Ownership Limitation, then the Holder shall not be entitled to participate in such Purchase Right to such extent (or beneficial ownership
of such shares of Common Stock as a result of such Purchase Right to such extent) and such Purchase Right to such extent shall be held
in abeyance for the Holder until such time, if ever, as its right thereto would not result in the Holder exceeding the Beneficial Ownership
Limitation).
(c) Pro
Rata Distributions. During such time as this Series H Preferred Stock is outstanding, if the Corporation declares or makes any
dividend or other distribution of its assets (or rights to acquire its assets) to holders of shares of Common Stock, by way of return
of capital or otherwise (including, without limitation, any distribution of cash, stock or other securities, property or options by way
of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar transaction) (a “Distribution”),
at any time after the issuance of this Series H Preferred Stock, then, in each such case, the Holder shall be entitled to participate
in such Distribution to the same extent that the Holder would have participated therein if the Holder had held the number of shares of
Common Stock acquirable upon complete conversion of this Series H Preferred Stock (without regard to any limitations on conversion
hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date of which a record is taken for
such Distribution, or, if no such record is taken, the date as of which the record holders of shares of Common Stock are to be determined
for the participation in such Distribution (provided, however, to the extent that the Holder’s right to participate
in any such Distribution would result in the Holder exceeding the Beneficial Ownership Limitation, then the Holder shall not be entitled
to participate in such Distribution to such extent (or in the beneficial ownership of any shares of Common Stock as a result of such Distribution
to such extent) and the portion of such Distribution shall be held in abeyance for the benefit of the Holder until such time, if ever,
as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).
(d) Fundamental
Transaction. If, at any time while this Series H Preferred Stock is outstanding, (i) the Corporation, directly or
indirectly, in one or more related transactions effects any merger or consolidation of the Corporation with or into another Person
and the Corporation is not the surviving Person, (ii) the Corporation, directly or indirectly, effects any sale, lease,
license, assignment, transfer, conveyance or other disposition of all or substantially all of its assets in one or a series of
related transactions, (iii) any direct or indirect purchase offer, tender offer or exchange offer is completed pursuant to
which holders of Common Stock are permitted to sell, tender or exchange their shares for other securities, cash or property and has
been accepted by the holders of 50% or more of the outstanding Common Stock, (iv) the Corporation, directly or indirectly, in
one or more related transactions effects any reclassification, reorganization or recapitalization of the Common Stock or any
compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash
or property, or (v) the Corporation, directly or indirectly, in one or more related transactions consummates a stock or share
purchase agreement or other business combination (including, without limitation, a reorganization, recapitalization, spin-off
or scheme of arrangement) with another Person whereby such other Person acquires more than 50% of the outstanding shares of Common
Stock (each a “Fundamental Transaction”), then, immediately prior but subject to the occurrence of the
Fundamental Transaction each outstanding share of Series H Preferred Stock shall automatically convert into shares of Common
Stock, without any action of or by the Holders or the Corporation, at the Conversion Ratio then in effect, and the Holders shall
receive, for each Conversion Share, such consideration, at the same time and subject to the same terms and conditions, as the other
holders of Common Stock pursuant to the terms of the Fundamental Transaction; provided, however, that such conversion
would not result in the Holder exceeding the Beneficial Ownership Limitation in the successor entity, or if no successor entity, the
Corporation. If holders of Common Stock are given any choice as to the securities, cash or property to be received in a Fundamental
Transaction, then the Holders shall be given the same choice.
(e) Calculations.
All calculations under this Section 7 shall be made to the nearest cent or the nearest 1/100th of a share, as the case may
be. For purposes of this Section 7, the number of shares of Common Stock deemed to be issued and outstanding as of a given
date shall be the sum of the number of shares of Common Stock (excluding any treasury shares of the Corporation) issued and outstanding.
(f) Notice
to the Holders.
(i) Adjustment
to Conversion Price. Whenever the Conversion Price is adjusted pursuant to any provision of this Section 7, the Corporation
shall promptly deliver to each record Holder by facsimile or email a notice setting forth the Conversion Price after such adjustment and
setting forth a brief statement of the facts requiring such adjustment.
(ii) Notice
to Allow Conversion by Holder. If (A) the Corporation shall declare a dividend (or any other distribution in whatever form) on
the Common Stock, (B) the Corporation shall declare a special nonrecurring cash dividend on or a redemption of the Common Stock applicable
to all holders of Common Stock, (C) the Corporation shall authorize the granting to all holders of the Common Stock of rights or
warrants to subscribe for or purchase any shares of capital stock of any class or of any rights, (D) the approval of any stockholders
of the Corporation shall be required in connection with any reclassification of the Common Stock, any consolidation or merger to which
the Corporation is a party, any sale or transfer of all or substantially all of the assets of the Corporation, or any compulsory share
exchange whereby the Common Stock is converted into other securities, cash or property, or (E) the Corporation shall authorize the
voluntary or involuntary dissolution, liquidation or winding up of the affairs of the Corporation, then, in each case, the Corporation
shall cause to be filed at each office or agency maintained for the purpose of conversion of this Series H Preferred Stock, and shall
cause to be delivered by facsimile or email to each record Holder at its last facsimile number or email address as it shall appear upon
the stock books of the Corporation, at least twenty (20) calendar days prior to the applicable record or effective date hereinafter specified,
a notice stating (x) the date on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights
or warrants, or if a record is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such
dividend, distributions, redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation,
merger, sale, transfer or share exchange is expected to become effective or close, and the date as of which it is expected that holders
of the Common Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable
upon such reclassification, consolidation, merger, sale, transfer or share exchange, provided that the failure to deliver such notice
or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required to be specified in such
notice. To the extent that any notice provided hereunder constitutes, or contains, material, non-public information regarding the Corporation
or any of the Subsidiaries, the Corporation shall simultaneously file such notice with the Commission pursuant to a Current Report on
Form 8-K. The Holder shall remain entitled to convert part or all of the shares of Series H Preferred Stock held by such Holder
during the 20-day period commencing on the date of such notice through the effective date of the event triggering such notice except as
may otherwise be expressly set forth herein.
Section 8. Miscellaneous.
(a) Notices.
Any and all notices or other communications or deliveries to be provided by the Holders hereunder shall be in writing and delivered
personally, by facsimile, by e-mail or sent by a nationally recognized overnight courier service, addressed to the Corporation, at
the address set forth above Attention: Chief Executive Officer, facsimile number (415) 371-8311, email: lconte@jaguar.health with a
copy sent to attention of the Corporation’s Chief Financial Officer, facsimile number (415) 371-8311, email:
clizak@jaguar.health or such other facsimile number or address as the Corporation may specify for such purposes by notice to the
Holders delivered in accordance with this Section 8(a). Any and all notices or other communications or deliveries
to be provided by the Corporation hereunder shall be in writing and delivered personally, by facsimile, by e-mail or sent by a
nationally recognized overnight courier service addressed to each record Holder at the facsimile number, e-mail address or address
of such Holder appearing on the books of the Corporation. Any notice or other communication or deliveries hereunder shall be deemed
given and effective on the earliest of (i) the time of transmission, if such notice or communication is delivered via facsimile
or e-mail at the facsimile number or e-mail address set forth in this Section 8(a) prior to 5:30 p.m. (New
York City time) on any Trading Day, (ii) the next Trading Day after the time of transmission, if such notice or communication
is delivered via facsimile or via e-mail at the facsimile number or e-mail address set forth in this Section 8(a) on
a day that is not a Trading Day or later than 5:30 p.m. (New York City time) on any Trading Day, (iii) the second Trading
Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service, or (iv) upon actual receipt
by the party to whom such notice is required to be given.
(b) Governing
Law. All questions concerning the construction, validity, enforcement and interpretation of this Certificate of Designation shall
be governed by and construed and enforced in accordance with the internal laws of the State of Delaware, without regard to the principles
of conflict of laws thereof. The rule of construction to the effect that any ambiguities are to be resolved against the drafting
party shall not be employed in the interpretation of this Certificate of Designation or any amendments thereto. All legal proceedings
concerning the interpretation, enforcement and defense of the transactions contemplated by this Certificate of Designation (whether brought
against a party hereto or its respective Affiliates, directors, officers, shareholders, employees or agents) shall be commenced in the
state and federal courts sitting in the State of Delaware, (the “Delaware Courts”).
(c) Uncertificated
Shares. The shares of Series H Preferred Stock shall be uncertificated.
(d) Waiver.
Any waiver by the Corporation or a Holder of a breach of any provision of this Certificate of Designation shall not operate as or be construed
to be a waiver of any other breach of such provision or of any breach of any other provision of this Certificate of Designation or a waiver
by any other Holders. The failure of the Corporation or a Holder to insist upon strict adherence to any term of this Certificate of Designation
on one or more occasions shall not be considered a waiver or deprive that party (or any other Holder) of the right thereafter to insist
upon strict adherence to that term or any other term of this Certificate of Designation on any other occasion. Any waiver by the Corporation
or a Holder must be in writing.
(e) Severability.
If any provision of this Certificate of Designation is invalid, illegal or unenforceable, the balance of this Certificate of Designation
shall remain in effect, and if any provision is inapplicable to any Person or circumstance, it shall nevertheless remain applicable to
all other Persons and circumstances. If it shall be found that any interest or other amount deemed interest due hereunder violates the
applicable law governing usury, the applicable rate of interest due hereunder shall automatically be lowered to equal the maximum rate
of interest permitted under applicable law.
(f) Next
Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business Day, such payment shall
be made or other obligation performed on the next succeeding Business Day.
(g) Headings.
The headings contained herein are for convenience only, do not constitute a part of this Certificate of Designation and shall not be deemed
to limit or affect any of the provisions hereof.
(h) Status
of Converted or Redeemed Preferred Stock. Any shares of Series H Preferred Stock that are converted, redeemed or otherwise acquired
by the Corporation or any of its subsidiaries in accordance with the terms of this Certificate of Designation shall be automatically and
immediately cancelled and retired and shall not be reissued, sold or transfer as shares of Series H Preferred Stock, and shall resume
the status of authorized but unissued shares of preferred stock and the Corporation may thereafter take such appropriate action (without
the need for stockholder action) as may be necessary to reduce the authorized number of shares of Series H Preferred Stock accordingly.
(i) Amendment.
In addition to any other vote or consent required by the Certificate of Incorporation (including this Certificate of Designation) or
required by law, any of the provisions, terms, rights, powers, preferences and other terms of the Series H Preferred Stock set
forth herein may be amended or waived on behalf of all Holders of Series H Preferred Stock by the affirmative written
consent or vote of the Holders of at least a majority of the shares of Series H Preferred Stock then outstanding.
*********************
RESOLVED, FURTHER, that the
chief executive officer, the president, the chief financial officer or any vice-president, and the secretary or any assistant secretary,
of the Corporation be and they hereby are authorized and directed to prepare and file this Certificate of Designation of Preferences,
Rights and Limitations in accordance with the foregoing resolution and the provisions of Delaware law.
IN WITNESS WHEREOF, the undersigned have executed
this Certificate this 28th day of June, 2023.
/s/ Lisa A. Conte |
|
/s/ Carol R. Lizak |
Name: Lisa A. Conte |
|
Name: Carol R. Lizak |
Title: Chief Executive Officer and President |
|
Title: Chief Financial Officer |
ANNEX A
NOTICE OF CONVERSION
(TO BE EXECUTED BY THE REGISTERED HOLDER IN ORDER
TO CONVERT SHARES OF PREFERRED STOCK)
The undersigned hereby elects to convert the number
of shares of Series H Convertible Preferred Stock (the “Preferred Stock”) indicated below into shares of common
stock, par value $0.0001 per share (the “Common Stock”), of Jaguar Health, Inc., a Delaware corporation (the “Corporation”),
according to the conditions hereof, as of the date written below. If shares of Common Stock are to be issued in the name of a Person other
than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto. No fee will be charged to the undersigned
for any conversion, except for any such transfer taxes.
Conversion calculations:
Date to Effect Conversion: |
Number of shares of Preferred Stock owned prior to Conversion: |
Number of shares of Preferred Stock to be Converted: |
Stated Value of shares of Preferred Stock to be Converted: |
Number of shares of Common Stock to be Issued: |
Applicable Conversion Price: |
Number of shares of Preferred Stock subsequent to Conversion: |
Address for Delivery: |
|
or |
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DWAC Instructions: |
|
Broker no: |
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Account no: |
|
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[HOLDER] |
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|
|
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By: |
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Name: |
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Title: |
Exhibit 10.1
THE EXCHANGE CONTEMPLATED HEREIN IS INTENDED
TO COMPORT WITH THE REQUIREMENTS OF SECTION 3(a)(9) OF THE SECURITIES ACT OF 1933, AS AMENDED.
EXCHANGE AGREEMENT
This
Exchange Agreement (this “Agreement”) is entered into as of June 28, 2023 (the “Effective Date”)
by and between [_______________________] (“Lender”), and Jaguar Health, Inc., a Delaware corporation (“Borrower”).
Capitalized terms used in this Agreement without definition shall have the meanings given to them in the Royalty Interest (as defined
below).
A. Company
previously sold and issued to Investor that certain Royalty Interest dated March 8, 2021 (the “Royalty Interest”)
pursuant to that certain Royalty Interest Purchase Agreement dated March 8, 2021 (the “Purchase Agreement,” and
together with the Royalty Interest and all other documents entered into in conjunction therewith, the “Transaction Documents”).
B. Subject
to the terms of this Agreement, Borrower and Investor desire to partition a new Royalty Interest in the Royalty Repayment Amount of $[____________]
(the “Partitioned Royalty”) from the Royalty Interest and then cause the outstanding balance of the Royalty Interest
to be reduced by an amount equal to the initial outstanding balance of the Partitioned Royalty.
C. Borrower
and Investor further desire to exchange (such exchange is referred to as the “Royalty Exchange”) the Partitioned Royalty
for [___] shares of the Company’s Series H Convertible Preferred Stock, par value $0.0001 (the “Preferred Stock”,
and such [___] shares of Preferred Stock, the “Exchange Shares”), according to the terms and conditions of this Agreement.
D. The
Royalty Exchange will consist of Investor surrendering the Partitioned Royalty in exchange for the Exchange Shares.
E. Other
than the surrender of the Partitioned Royalty, no consideration of any kind whatsoever shall be given by Investor to Borrower in connection
with this Agreement.
F. Investor
and Borrower now desire to exchange the Partitioned Royalty for the Exchange Shares on the terms and conditions set forth herein.
NOW, THEREFORE, for good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree as follows:
1. Recitals
and Definitions. Each of the parties hereto acknowledges and agrees that the recitals set forth above in this Agreement are true and
accurate, are contractual in nature, and are hereby incorporated into and made a part of this Agreement.
2. Partition.
Effective as of the date hereof, Borrower and Investor agree that the Partitioned Royalty is hereby partitioned from the Royalty Interest.
Following such partition of the Royalty Interest, Borrower and Investor agree that the Royalty Interest shall remain in full force and
effect, provided that the outstanding balance of the Royalty Interest shall be reduced by an amount equal to the initial outstanding balance
of the Partitioned Royalty. For avoidance of doubt, the rights, duties, obligations, remedies of Borrower and Investor, and other terms
and conditions of the Royalty Interest shall remain unchanged upon the entering into of this Agreement, except with respect to the reduction
in the outstanding balance by the amount of the Partitioned Royalty.
3. Issuance
of Shares. Pursuant to the terms and conditions of this Agreement, the Exchange Shares shall be delivered to Investor on or before
June 30, 2023 and the Royalty Exchange shall occur with Investor surrendering the Partitioned Royalty to Borrower on the date the
Exchage Shares are issued to Investor (the “Issuance Date” ). On the Issuance Date, the Partitioned Royalty shall be
cancelled and all obligations of Borrower under the Partitioned Royalty shall be deemed fulfilled. All Exchange Shares shall be issued
in book entry form.
4. Closing.
The closing of the transaction contemplated hereby (the “Closing”) along with the delivery of the Exchange Shares to
Investor shall occur on the date that is mutually agreed to by Borrower and Investor by means of the exchange by express courier and email
of .pdf documents, but shall be deemed to have occurred at the offices of Hansen Black Anderson Ashcraft PLLC in Lehi, Utah.
5. Holding
Period, Tacking and Legal Opinion. Borrower represents, warrants and agrees that for the purposes of Rule 144
(“Rule 144”) of the Securities Act of 1933, as amended (the “Securities Act”), the
holding period of the Partitioned Royalty and the Exchange Shares will include Investor’s holding period of the Royalty
Interest from [_____________]. Borrower agrees not to take a position contrary to this Section 5 in any document, statement,
setting, or situation. The Exchange Shares are being issued in substitution of and exchange for and not in satisfaction of
the Partitioned Royalty. The Exchange Shares shall not constitute a novation or satisfaction and accord of the Partitioned Royalty.
Borrower acknowledges and understands that the representations and agreements of Borrower in this Section 5 are a material
inducement to Investor’s decision to consummate the transactions contemplated herein.
6. Borrower’s
Representations, Warranties and Agreements. In order to induce Investor to enter into this Agreement, Borrower, for itself, and for
its affiliates, successors and assigns, hereby acknowledges, represents, warrants and agrees as follows: (a) Borrower has full power
and authority to enter into this Agreement and to incur and perform all obligations and covenants contained herein, all of which have
been duly authorized by all proper and necessary action, (b) no consent, approval, filing or registration with or notice to any governmental
authority is required as a condition to the validity of this Agreement or the performance of any of the obligations of Borrower hereunder,
(c) no Event of Default has occurred under the Royalty Interest and any Events of Default that may have occurred thereunder have
not been, and are not hereby, waived by Investor, (d) except as specifically set forth herein, nothing herein shall in any manner
release, lessen, modify or otherwise affect Borrower’s obligations under the Royalty Interest, (e) the issuance of the Exchange
Shares is duly authorized by all necessary corporate action and the Exchange Shares are validly issued, fully paid and non-assessable,
free and clear of all taxes, liens, claims, pledges, mortgages, restrictions, obligations, security interests and encumbrances of any
kind, nature and description, (f) Borrower has not received any consideration in any form whatsoever for entering into this Agreement,
other than the surrender of the Partitioned Royalty, and (g) Borrower has taken no action which would give rise to any claim by any
person for a brokerage commission, placement agent or finder’s fee or other similar payment by Borrower related to this Agreement.
7. Investor’s
Representations, Warranties and Agreements. In order to induce Borrower to enter into this Agreement, Investor, for itself, and
for its affiliates, successors and assigns, hereby acknowledges, represents, warrants and agrees as follows: (a) Investor has full
power and authority to enter into this Agreement and to incur and perform all obligations and covenants contained herein, all of which
have been duly authorized by all proper and necessary action, (b) no consent, approval, filing or registration with or notice to
any governmental authority is required as a condition to the validity of this Agreement or the performance of any of the obligations of
Investor hereunder, (c) Investor has taken no action which would give rise to any claim by any person for a brokerage commission,
placement agent or finder’s fee or other similar payment by Borrower related to this Agreement, (d) Investor is not currently
an affiliate of the Borrower and has not been an affiliate of the Borrower for the prior three months, and (f) Investor, together
with its affiliates, does not, and will not following the receipt of the Exchange Shares, beneficially own more than 9.99% of the number
of shares of Borrower’s common stock, par value $0.0001 (the “Common Stock”) outstanding on the Effective Date.
For purposes of Section 7(f), beneficial ownership of Common Stock will be determined pursuant to Section 13(d) of the
Securities Exchange Act of 1934, as amended.
8. Governing
Law; Venue. This Agreement shall be construed and enforced in accordance with, and all questions concerning the construction, validity,
interpretation and performance of this Agreement shall be governed by, the internal laws of the State of Utah, without giving effect to
any choice of law or conflict of law provision or rule (whether of the State of Utah or any other jurisdictions) that would cause
the application of the laws of any jurisdictions other than the State of Utah. The provisions set forth in the Purchase Agreement to determine
the proper venue for any disputes are incorporated herein by this reference. The parties agree that the Arbitration Provisions shall apply
to any dispute that may arise between Borrower and Investor under this Agreement. BORROWER HEREBY IRREVOCABLY WAIVES ANY RIGHT
IT MAY HAVE TO, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION WITH OR ARISING
OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY.
9. Counterparts.
This Agreement may be executed in any number of counterparts with the same effect as if all signing parties had signed the same document.
All counterparts shall be construed together and constitute the same instrument. The exchange of copies of this Agreement and of signature
pages by facsimile transmission or other electronic transmission (including email) shall constitute effective execution and delivery
of this Agreement as to the parties and may be used in lieu of the original Agreement for all purposes. Signatures of the parties transmitted
by facsimile transmission or other electronic transmission (including email) shall be deemed to be their original signatures for all purposes.
10. Attorneys’
Fees. In the event of any arbitration or action at law or in equity to enforce or interpret the terms of this Agreement, the parties
agree that the party who is awarded the most money shall be deemed the prevailing party for all purposes and shall therefore be entitled
to an additional award of the full amount of the attorneys’ fees and expenses paid by such prevailing party in connection
with the arbitration, litigation and/or dispute without reduction or apportionment based upon the individual claims or defenses
giving rise to the fees and expenses. Nothing herein shall restrict or impair an arbitrator’s or a court’s power to
award fees and expenses for frivolous or bad faith pleading.
11. No
Reliance. Borrower acknowledges and agrees that neither Investor nor any of its officers, directors, members, managers, equity holders,
representatives or agents has made any representations or warranties to Borrower or any of its agents, representatives, officers, directors,
or employees except as expressly set forth in this Agreement and the Transaction Documents and, in making its decision to enter into the
transactions contemplated by this Agreement, Borrower is not relying on any representation, warranty, covenant or promise of Investor
or its officers, directors, members, managers, equity holders, agents or representatives other than as set forth in this Agreement.
12. Severability.
If any part of this Agreement is construed to be in violation of any law, such part shall be modified to achieve the objective of the
parties to the fullest extent permitted and the balance of this Agreement shall remain in full force and effect.
13. Entire
Agreement. This Agreement, together with the Transaction Documents, and all other documents referred to herein, supersedes all other
prior oral or written agreements between Borrower, Investor, its affiliates and persons acting on its behalf with respect to the
matters discussed herein, and this Agreement and the instruments referenced herein contain the entire understanding of the parties with
respect to the matters covered herein and therein and, except as specifically set forth herein or therein, neither Investor nor Borrower
makes any representation, warranty, covenant or undertaking with respect to such matters.
14. Amendments.
This Agreement may be amended, modified, or supplemented only by written agreement of the parties. No provision of this Agreement may
be waived except in writing signed by the party against whom such waiver is sought to be enforced.
15. Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their respective successors and assigns.
This Agreement or any of the severable rights and obligations inuring to the benefit of or to be performed by Investor hereunder may be
assigned by Investor to a third party, including its financing sources, in whole or in part. Borrower may not assign this Agreement or
any of its obligations herein without the prior written consent of Investor.
16. Continuing
Enforceability; Conflict Between Documents. Except as otherwise modified by this Agreement, the Royalty Interest and each of the other
Transaction Documents shall remain in full force and effect, enforceable in accordance with all of its original terms and provisions.
This Agreement shall not be effective or binding unless and until it is fully executed and delivered by Investor and Borrower. If there
is any conflict between the terms of this Agreement, on the one hand, and the Royalty Interest or any other Transaction Document, on the
other hand, the terms of this Agreement shall prevail.
17. Time
of Essence. Time is of the essence with respect to each and every provision of this Agreement.
18. Notices.
Unless otherwise specifically provided for herein, all notices, demands or requests required or permitted under this Agreement to be given
to Borrower or Investor shall be given as set forth in the “Notices” section of the Purchase Agreement.
19. Further
Assurances. Each party shall do and perform or cause to be done and performed, all such further acts and things, and shall execute
and deliver all such other agreements, certificates, instruments and documents, as the other party may reasonably request in order to
carry out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.
[Remainder of page intentionally left blank]
IN WITNESS WHEREOF, the undersigned
have executed this Agreement as of the date first set forth above.
|
COMPANY: |
|
|
|
JAGUAR
HEALTH, INC. |
|
|
|
By: |
|
|
Name: |
|
|
Title: |
|
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|
|
INVESTOR: |
|
|
|
[_________________________] |
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|
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By: |
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[_______________] |
[Signature Page to Exchange
Agreement]
Exhibit 10.2
FIRST
AMENDMENT
TO
STANDSTILL AGREEMENT
This FIRST
AMENDMENT (this “Amendment”) to the Standstill Agreement (as hereinafter defined) is made effective as of June 28,
2023 (the “Amendment Effective Date”) by and among Iliad Research and Trading,
L.P., a Utah limited partnership, or its successors or assigns (“Iliad”), Uptown
Capital, LLC, a Utah limited liability company (f/k/a Irving Park Capital, LLC), or its successors or assigns (“Uptown”),
Streeterville Capital, LLC, a Utah limited liability company, or its successors or assigns
(“Streeterville,” and together with Iliad and Uptown, “Investor”), Jaguar
Health, Inc., a Delaware corporation (“Jaguar”), and Napo Pharmaceuticals, Inc.,
a Delaware corporation and subsidiary of Jaguar (“Napo,” and together with Jaguar, “Company”).
WHEREAS, Company and Investor
are parties to that certain Standstill Agreement dated as of May 8, 2023 (the “Standstill Agreement”);
WHEREAS, Jaguar desires to
issue to Investor, and Investor desires to acquire from Jaguar, up to $2.5 million worth of shares of convertible preferred stock in exchange
for the outstanding Royalty Interests in one or more exchange transactions pursuant to Section 3(a)(9) of the Securities Act,
whereby the effective exchange price shall equal the Minimum Price (as defined pursuant to Nasdaq Listing Rule 5635(d)) as of the
date of the definitive agreement for the initial exchange transaction (the “3(a)(9) Transaction”); and
WHEREAS, Company and Investor
desire to revise certain terms set forth in the Standstill Agreement to permit (i) Jaguar to consummate the 3(a)(9) Transaction
without triggering the termination of the Standstill Period, and (ii) Investor to (A) consummate the 3(a)(9) Transaction
during the Standstill Period and (B) sell all shares of Common Stock beneficially owned by Investor immediately prior to the consummation
of the 3(a)(9) Transaction during the Standstill Period.
NOW, THEREFORE, in consideration
of the foregoing and upon the terms and conditions set forth below, the parties agree as follows:
1. Definitions.
Capitalized terms used in this Amendment and not otherwise defined in this Amendment shall have the meanings set forth in the Standstill
Agreement.
2. Effective
Date. This Amendment shall become effective as of the Amendment Effective Date.
3. Amendments.
(a) Paragraph
D of the recitals of the Standstill Agreement is hereby deleted in its entirety and replaced as follows:
D. Company
has requested that Investor, for a period beginning on the Effective Date and ending on the earliest of: (1) the date that is
six (6) months following the Effective Date, (2) the date of the public announcement of the probability value (also known
as the “P-value”) in Jaguar’s OnTarget Phase 3 clinical trial of crofelemer for prophylaxis of cancer
therapy-related diarrhea, and (3) the date of any offering or sale of any debt or equity securities (or instruments convertible
into equity securities), including without limitation any at-the-market offering (also known as an ATM Offering), but excluding any
Exempt Issuance (the “Standstill Period”), (a) allow Company to refrain from making the Royalty Payments,
including any Royalty Payments due and payable as of the Effective Date, and (b) refrain from buying, selling, or otherwise
trading in Jaguar’s Common Stock or Common Stock Equivalents, except for the Permitted Transactions, all as more fully set
forth in this Agreement (collectively, the “Standstill”). For purposes of this Agreement, “Exempt
Issuance” means the issuance of (i) shares of Common Stock, any securities of Jaguar which would entitle the holder
thereof to acquire at any time Common Stock (“Common Stock Equivalents”), options, or other equity awards to
employees, officers, directors, or consultants of Jaguar pursuant to any stock or option plan or other equity award plan duly
adopted for such purpose by a majority of the non-employee members of the Board of Directors of Jaguar or a majority of the members
of a committee of non-employee directors established for such purpose, (ii) securities upon the exercise or exchange of or
conversion of any securities exercisable or exchangeable for or convertible into shares of Common Stock issued and outstanding on
the date of this Agreement, solely at the election of the holder, provided that such securities have not been amended since the date
of this Agreement to increase the number of such securities or to decrease the exercise price, exchange price or conversion price of
such securities (except for such decreases in exercise, exchange or conversion price in accordance with the terms of such
securities) or to extend the term of such securities, (iii) securities in a contemplated private placement with certain
accredited investors of up to $3 million (the “PIPE”), including any shares of Common Stock issuable upon the
exercise or exchange of or conversion of such securities; (iv) securities in a privately negotiated transaction to vendors,
services providers, strategic partners or potential strategic partners of Jaguar which are not issued for capital-raising
purposes, and (v) securities in exchange for up to $2.5 million worth of outstanding Royalty Interests pursuant to
Section 3(a)(9) of the Securities Act (the “3(a)(9) Exchange”), including any shares of Common
Stock issuable upon the exercise or exchange of or conversion of such securities (collectively, the “3(a)(9) Exchange
Securities”). For purposes of this Agreement, “Permitted Transactions” means: (i) the acquisition
by Investor of the 3(a)(9) Exchange Securities; and (ii) the sale by Investor of up to 100% of the aggregate number of
shares of Common Stock beneficially owned by Investor immediately prior to the consummation of the 3(a)(9) Exchange. For the
avoidance of doubt, the 3(a)(9) Exchange Securities shall be subject to the Standstill and may not be sold or otherwise traded
in by Investor during the Standstill Period.
4. Effect
of Amendment. Except as expressly amended in this Amendment, all terms and conditions of the Standstill Agreement shall remain in
full force and effect.
5. Counterparts.
This Amendment may be executed in counterparts, each of which shall be deemed to be an original instrument enforceable in accordance with
its terms and all of which shall constitute but one and the same agreement of the parties.
6. Dispute
Resolutions; Governing Law. The provisions of Sections 11, 12 and 13 of the Standstill Agreement shall apply
equally to this Amendment.
[Remainder of page intentionally left blank;
signature page follows]
IN WITNESS WHEREOF, the undersigned
have caused this Amendment to be executed by their duly authorized officers or representatives as of the Amendment Effective Date.
|
COMPANY: |
|
|
|
Jaguar
Health, Inc. |
|
|
|
By: |
/s/
Lisa Conte |
|
|
Lisa
Conte, President and CEO |
|
|
|
Napo
Pharmaceuticals, Inc. |
|
|
|
By: |
/s/
Lisa Conte |
|
|
Lisa
Conte, President and CEO |
[Signature Page to First
Amendment to Standstill Agreement]
|
INVESTOR: |
|
|
|
Streeterville
Capital, LLC |
|
|
|
By: |
/s/ John M. Fife |
|
|
John M. Fife, President |
|
|
|
Iliad
Research and Trading, L.P. |
|
|
|
By:
Iliad Management, LLC, its General Partner |
|
|
|
By:
Fife Trading, Inc., its Manager |
|
|
|
|
By: |
/s/
John
M. Fife |
|
|
John
M. Fife, President |
|
|
|
Uptown
Capital, LLC |
|
|
|
By: |
/s/ John M. Fife |
|
|
John M. Fife, President |
[Signature Page to First
Amendment to Standstill Agreement]
v3.23.2
Cover
|
Jun. 28, 2023 |
Cover [Abstract] |
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Document Type |
8-K
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Amendment Flag |
false
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Document Period End Date |
Jun. 28, 2023
|
Current Fiscal Year End Date |
--12-31
|
Entity File Number |
001-36714
|
Entity Registrant Name |
JAGUAR HEALTH, INC.
|
Entity Central Index Key |
0001585608
|
Entity Tax Identification Number |
46-2956775
|
Entity Incorporation, State or Country Code |
DE
|
Entity Address, Address Line One |
200 Pine Street
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Entity Address, Address Line Two |
Suite 400
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Entity Address, City or Town |
San Francisco
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Entity Address, State or Province |
CA
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Entity Address, Postal Zip Code |
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City Area Code |
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