NEW YORK, Dec. 22, 2020 /PRNewswire-PRWeb/ -- Substances
present in cooked meats are associated with increased wheezing in
children, Mount Sinai researchers
report. Their study, published in Thorax, highlights
pro-inflammatory compounds called advanced glycation end-products
(AGEs) as an example of early dietary risk factors that may have
broad clinical and public health implications for the prevention of
inflammatory airway disease.
Asthma prevalence among children in the United States has risen over the last few
decades. Researchers found that dietary habits established earlier
in life may be associated with wheezing and potentially the future
development of asthma.
Researchers examined 4,388 children between 2 and 17 years old
from the 2003-2006 National Health and Nutrition Examination Survey
(NHANES), a program of the National Center for Health Statistics,
which is part of the U.S. Centers for Disease Control and
Prevention. It is designed to evaluate the health and nutritional
status of adults and children in the
United States through interviews and physical
examinations.
The researchers used NHANES survey data to evaluate associations
between dietary AGE and meat consumption frequencies, and
respiratory symptoms. They found that higher AGE intake was
significantly associated with increased odds of wheezing,
importantly including wheezing that disrupted sleep and exercise,
and that required prescription medication. Similarly, higher intake
of non-seafood meats was associated with wheeze-disrupted sleep and
wheezing that required prescription medication.
"We found that higher consumption of dietary AGEs, which are
largely derived from intake of non-seafood meats, was associated
with increased risk of wheezing in children, regardless of overall
diet quality or an established diagnosis of asthma," said
Jing Gennie Wang, MD, lead author of
the study, and a former fellow in Pulmonary, Critical Care and
Sleep Medicine at the Icahn School of Medicine at Mount Sinai.
"Research identifying dietary factors that influence respiratory
symptoms in children is important, as these risks are potentially
modifiable and can help guide health recommendations. Our findings
will hopefully inform future longitudinal studies to further
investigate whether these specific dietary components play a role
in childhood airways disease such as asthma," said Sonali Bose, MD, senior author, and Assistant
Professor of Pulmonary, Critical Care and Sleep Medicine and
Pediatrics at Icahn School of Medicine at Mount Sinai.
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SOURCE Mount Sinai Health System